1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine

Base Information

• Chemical Name: 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine
• CAS No.: 846023-54-9
• Molecular Formula: C15H23 N3 O4
• Molecular Weight: 309.365
• Mol file: 846023-54-9.mol

Synonyms:1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine

Chemical Property of 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 451.167oC at 760 mmHg
• Flash Point: 226.658oC
• PSA: 70.76000
• Density: 1.159g/cm3
• LogP: 2.01870

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine

There total 2 articles about 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-methyl-piperazine (109-01-3) + 1-(2-methoxy-5-nitrophenoxy)-3-chloropropane (92878-95-0) → 1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine (846023-54-9)

Guidance literature:

With sodium iodide; In 1,2-dimethoxyethane; for 8h; Heating / reflux;

Reference yield:

5-nitroguaiacol (636-93-1) → 1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine (846023-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / isopropyl alcohol / 0.5 h / 40 °C

2: sodium iodide / 1,2-dimethoxyethane / 8 h / Reflux

With sodium iodide; sodium hydroxide; In 1,2-dimethoxyethane; isopropyl alcohol;

Reference yield:

1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine (846023-54-9) → 4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenylamine (846023-55-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In isopropyl alcohol; for 5h;

upstream raw materials:

1-methyl-piperazine

1-(2-methoxy-5-nitrophenoxy)-3-chloropropane

5-nitroguaiacol

Downstream raw materials:

4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenylamine

bosutinib

2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-{4-methoxy-3-[3-(4-methylpiperazin-1-yl)-propoxy]-phenylamino}-acrylamide