92878-95-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is used as a chemical intermediate for the synthesis of pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is utilized as an intermediate in the production of pesticides. Its involvement in the synthesis process helps in creating effective pest control solutions for agricultural applications.
Given its potential hazards, 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene should be handled with care due to its toxic nature, which may pose risks to human health and the environment.

Upstream product

• 6940-76-7 1-iodo-3-chloro-propane 
• 636-93-1 5-nitroguaiacol 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 846023-54-9 1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine 
• 380843-75-4 bosutinib 
• 846023-56-1 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-{4-methoxy-3-[3-(4-methylpiperazin-1-yl)-propoxy]-phenylamino}-acrylamide 
• 846023-55-0 4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenylamine 
• 1292318-17-2 4-[3-(2-methoxy-5-nitrophenoxy)propyl]morpholine 
• 1292318-18-3 4-methoxy-3-(3-morpholinopropoxy)aniline 
• 846023-25-4 3-(3-chloropropoxy)-4-methoxyaniline 

Relevant academic research and scientific papers

Method for preparing bosutinib intermediate

The invention provides a method for preparing a bosutinib intermediate. The method comprises the following steps: A, adding SM-1, 1-bromo-3-chloropropane and an acid-binding agent into a reaction solvent, controlling the temperature until the reaction is

Identification of highly potent BTK and JAK3 dual inhibitors with improved activity for the treatment of B-cell lymphoma

The BTK and JAK3 receptor tyrosine kinases are two validated and therapeutically amenable targets in the treatment of B-cell lymphomas. Here we report the identification of several classes of pyrimidine derivatives as potent BTK and JAK3 dual inhibitors.

HISTONE METHYLTRANSFERASE INHIBITORS

The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta- thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS JAK2 KINASE INHIBITORS

Pyrimidine-2,4-diamines derivatives having activity as JAK2 kinase inhibitors are disclosed, as well as pharmaceutical compositions and methods for using the same in the treatment of cancer and other JAK2 kinase-associated conditions.

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.

PHOTOINDUCED INTRAMOLECULAR SUBSTITUTION-III PHOTOCYCLIZATION OF ω-ANILINOALKYL m-NITROPHENYL ETHERS

Irradiation of 1-(m-nitrophenoxy)-ω-anilinoalkanes, m-O2NC6H4O(CH2)nNHPh (n = 2 and 3) and their 1-(2-methoxy-5-nitrophenoxy) analogs induced intramolecular cyclization in which a hydrogen or methoxyl