2-(3,5-Dichlorophenyl)-1H-imidazole-5-methanol

Base Information

Chemical Name:2-(3,5-Dichlorophenyl)-1H-imidazole-5-methanol
CAS No.:188257-68-3
Molecular Formula:C₁₀H₈Cl₂N₂O
Molecular Weight:243.092
Hs Code.:
DSSTox Substance ID:DTXSID101245676

Synonyms:SCHEMBL23778668;DTXSID101245676;AKOS012409191;188257-68-3;2-(3,5-Dichlorophenyl)-1H-imidazole-5-methanol;[2-(3,5-Dichlorophenyl)-1H-imidazol-4-yl]methanol, AldrichCPR

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,5-Dichlorophenyl)-1H-imidazole-5-methanol

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:242.0013683
Heavy Atom Count:15
Complexity:208

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C=C1Cl)Cl)C2=NC=C(N2)CO

Technology Process of 2-(3,5-Dichlorophenyl)-1H-imidazole-5-methanol

There total 2 articles about 2-(3,5-Dichlorophenyl)-1H-imidazole-5-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 62147-49-3
1,3-dihydroxyacetone dimer

: 188257-67-2
3,5-dichlorobenzamidine hydrochloride

: 188257-68-3
2-(3,5-dichlorophenyl)-4-hydroxymethylimidazole

Guidance literature:: With ammonium hydroxide; ammonium chloride; In tetrahydrofuran; for 0.75h; Heating;
DOI:10.1002/(SICI)1099-1344(199702)39:2<123::AID-JLCR959>3.0.CO;2-W

Reference yield:

: 6575-00-4
3,5-dichlorobenzonitrile

: 188257-68-3
2-(3,5-dichlorophenyl)-4-hydroxymethylimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LiN(TMS)2, 2.) 3.0 N aq. HCl / 1.) Et₂O, RT, 3 h, 2.) Et₂O

2: 68 percent / NH₄Cl, conc. NH₄OH / tetrahydrofuran / 0.75 h / Heating

With hydrogenchloride; ammonium hydroxide; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/(SICI)1099-1344(199702)39:2<123::AID-JLCR959>3.0.CO;2-W

Reference yield:

: 188257-68-3
2-(3,5-dichlorophenyl)-4-hydroxymethylimidazole

: tritiated 2-phenyl-4-[4-(2-pyrimidyl)piperazinyl]methylimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / Heating

2: Et₃N / CHCl₃ / 0.5 h

3: aq. NaI, chloramine-T hydrate / methanol / 0.17 h

4: 27 percent / T₂, Et₃N / 10percent Pd/C / methanol / 1 h

With thionyl chloride; tritium; chloroamine-T; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; chloroform;
DOI:10.1002/(SICI)1099-1344(199702)39:2<123::AID-JLCR959>3.0.CO;2-W