4-(1H-pyrazol-5-yl)phenol

Base Information

• Chemical Name: 4-(1H-pyrazol-5-yl)phenol
• CAS No.: 68535-53-5
• Molecular Formula: C9H8 N2 O
• Molecular Weight: 160.175
• Hs Code.: 2933199090
• Mol file: 68535-53-5.mol

Synonyms:4-(1(2)H-pyrazol-3-yl)-phenol;3-(4-hydroxyphenyl)-1H-pyrazole;4-pyrazol-3-yl-phenol;4-(2H-Pyrazol-3-yl)phenol;

Chemical Property of 4-(1H-pyrazol-5-yl)phenol

Chemical Property:

• Melting Point: 165-168 °C(Solv: ethanol (64-17-5))
• Boiling Point: 398.4±17.0 °C(Predicted)
• PKA: 9.17±0.15(Predicted)
• PSA: 48.91000
• Density: 1.284±0.06 g/cm3(Predicted)
• LogP: 1.78230
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-(1H-pyrazol-5-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1H-pyrazol-5-yl)phenol

There total 5 articles about 4-(1H-pyrazol-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-p-methoxyphenylpyrazole (27069-17-6) → 3-(4-hydroxyphenyl)-1H-pyrazole (68535-53-5)

Guidance literature:

With water; hydrogen bromide; for 12h; Inert atmosphere; Reflux;

DOI:10.1007/s13738-012-0126-z

Reference yield:

C11H12N2O2 → 3-(4-hydroxyphenyl)-1H-pyrazole (68535-53-5)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 17h;

DOI:10.1007/s13738-012-0126-z

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 3-(4-hydroxyphenyl)-1H-pyrazole (68535-53-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethanolate / diethyl ether / 0 - 20 °C

2: hydrazine hydrate; acetic acid / ethanol / Reflux

3: hydrogen bromide; water / 12 h / Inert atmosphere; Reflux

With water; hydrogen bromide; sodium ethanolate; hydrazine hydrate; acetic acid; In diethyl ether; ethanol;

DOI:10.1007/s13738-012-0126-z

upstream raw materials:

1-(4-methoxyphenyl)ethanone

3-p-methoxyphenylpyrazole

3-(4-methoxy-phenyl)-3-oxo-propionaldehyde

Downstream raw materials:

{2-[4-(1H-pyrazol-3-yl)-phenoxy]-ethyl}-carbamic acid benzyl ester

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