Benzenebutanoicacid, 4-chloro-3-methyl-a,g-dioxo-, ethyl ester

Base Information

• Chemical Name: Benzenebutanoicacid, 4-chloro-3-methyl-a,g-dioxo-, ethyl ester
• CAS No.: 475471-20-6
• Molecular Formula: C13H13 Cl O4
• Molecular Weight: 268.697
• Mol file: 475471-20-6.mol

Synonyms:Ethyl4-(4-chloro-3-methylphenyl)-2,4-dioxobutanoate

Chemical Property of Benzenebutanoicacid, 4-chloro-3-methyl-a,g-dioxo-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenebutanoicacid, 4-chloro-3-methyl-a,g-dioxo-, ethyl ester

There total 1 articles about Benzenebutanoicacid, 4-chloro-3-methyl-a,g-dioxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

oxalic acid diethyl ester (95-92-1) + 4-chloro-3-methylacetophenone (37074-39-8) → 4-(4-chloro-3-methylphenyl)-2,4-dioxobutyric acid ethyl ester (475471-20-6)

Guidance literature:

4-chloro-3-methylacetophenone; With potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; n-heptane; at -78 ℃; for 0.916667h;

oxalic acid diethyl ester; In tetrahydrofuran; diethyl ether; n-heptane; at 20 ℃; for 72h;

DOI:10.1002/jlcr.952

Reference yield: 36.0%

4-(4-chloro-3-methylphenyl)-2,4-dioxobutyric acid ethyl ester (475471-20-6) + N-benzylsulfamide (14101-58-7) → 2-benzyl-3-(4-chloro-3-methylphenyl)-1,1-dioxo-1,2-dihydro-1λ6-1,2,6-thiadiazine-5-carboxylic acid ethyl ester (936756-40-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 72h; Heating;

DOI:10.1016/j.bmc.2007.07.056

Reference yield: 7.0%

4-(4-chloro-3-methylphenyl)-2,4-dioxobutyric acid ethyl ester (475471-20-6) + N-(2,4-dichlorobenzyl)sulfamide (4960-51-4) → 2-(2,4-dichlorobenzyl)-3-(4-chloro-3-methylphenyl)-1,1-dioxo-1,2-dihydro-1λ6-1,2,6-thiadiazine-5-carboxylic acid ethyl ester (936756-69-3)

Guidance literature:

With hydrogenchloride; In ethanol; for 96h; Heating;

DOI:10.1016/j.bmc.2007.07.056

upstream raw materials:

oxalic acid diethyl ester

4-chloro-3-methylacetophenone

Downstream raw materials:

5-(4-chloro-3-methylphenyl)-1-H-pyrazole-3-carboxylic acid

5-(4-chloro-3-methyl-phenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylic acid

5-(4-chloro-3-methyl-phenyl)-1H-pyrazole-3-carbonyl chloride

1-(4-methylbenzyl)-5-(4-chloro-3-methylphenyl)pyrazole-3-carboxylic acid chloride

Refernces