14101-58-7

Basic information

• Product Name: SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-(phenylMethyl)-
• Synonyms: SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-(phenylMethyl)-;(SULFAMOYL AMINO) METHYL BENZENE;N-Benzylaminosulfonamide
• CAS NO: 14101-58-7
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 453.74066
• Mol File: 14101-58-7.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-(phenylMethyl)-(14101-58-7)
• EPA Substance Registry System: SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-(phenylMethyl)-(14101-58-7)

Safety Data

• Hazardous Substances Data: 14101-58-7(Hazardous Substances Data)

Usage

General Description

Sulfamethazine, N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-(phenylmethyl)-, is a chemical compound with antimicrobial properties. It belongs to the class of sulfonamide antibiotics and is often used to treat bacterial infections in animals. It works by inhibiting the growth of bacteria by inhibiting enzymes necessary for DNA replication. SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-(phenylMethyl)- is commonly used in veterinary medicine to treat a variety of bacterial infections, including respiratory and urinary tract infections, and is also used as a feed additive for livestock to promote growth and prevent disease.

Upstream product

• 147000-78-0 N¹-BOC-N³-benzylsulfamide 
• 153028-15-0 tert-Butyl benzyl(sulfamoyl)carbamate 
• 100-46-9 benzylamine 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 371-40-4 4-fluoroaniline 
• 107-85-7 1-amino-3-methylbutane 
• 5631-35-6 1-[4,4-bis(4-fluorophenyl)butyl]piperazine 
• 62-53-3 aniline 
• 104-94-9 4-methoxy-aniline 
• 110-89-4 piperidine 

Downstream Products

• 1432732-06-3 N-(N-benzylsulfamoyl)acetamide 
• 1393813-59-6 C₂₆H₂₇BrN₆O₄S 
• 441795-38-6 C₂₅H₂₅BrN₆O₄S 
• 441795-23-9 C₂₃H₂₀BrClN₆O₄S 
• 1393813-58-5 C₂₄H₂₃BrN₆O₄S 
• 1393813-57-4 C₂₃H₂₁BrN₆O₄S 
• 441795-37-5 C₂₁H₂₄N₄O₄S 
• 441795-22-8 C₁₉H₁₉ClN₄O₄S 
• 441797-17-7 C₂₀H₂₁ClN₄O₆S 
• 441797-35-9 C₁₉H₁₉ClN₄O₂S 
• 441797-27-9 C₁₇H₁₄Cl₂N₄O₂S 
• 441797-33-7 C₁₈H₁₇ClN₄O₂S 
• 441797-36-0 C₁₇H₁₅ClN₄O₂S 

Relevant articles and documents

Affinity of sulfamates and sulfamides to carbonic anhydrase II isoform: Experimental and molecular modeling approaches

Sixteen aromatic and aliphatic sulfamides and sulfamates were synthesized and tested in their inhibition to carbonic anhydrase CAII activity. The weaker inhibition pattern shown by sulfamides as compared to sulfamates is interpreted in this research by means of molecular modeling techniques, including known inhibitors (topiramate and its sulfamide cognate) in the analysis. The results nicely explain the origin of the inhibitory activity, which is not only related to positive interactions of the ligand with the active site residues but also to the solvation pattern characteristic of each ligand.

SULFAMIDE LINKER, CONJUGATES THEREOF, AND METHODS OF PREPARATION

The present invention relates to a compound comprising an alpha-end and an omega-end, the compound comprising on the alpha-end a reactive group Qlcapable of reacting with a functional group F1present on a biomolecule and on the omega-end a target molecule, the compound further comprising a group according to formula (1) or a salt thereof: Said compound may also be referred to as a linker-conjugate. The invention also relates to a process for the preparation of a bioconjugate, the process comprising the step of reacting a reactive group Q1of a linker-conjugate according to the invention with a functional group F1of a biomolecule. The invention further relates to a bioconjugate obtainable by the process according to the invention. In a preferred embodiment, the invention concerns a process for the preparation of a bioconjugate via a cycloaddition, such as a (4+2)-cycloaddition (e.g. a Diels-Alder reaction) or a (3+2)-cycloaddition (e.g. a 1,3-dipolar cycloaddition).

Simple, rapid, and clean condensation of sulfonamide and maleic anhydride derivatives: Synthesis of novel 1H- Pyrrole-2,5-diones under heterogeneous conditions

H6P2W18O62is used as an efficient catalyst for the synthesis of novel N-substituted sulfonyl maleimides (1H-Pyrrole-2,5-diones) via the condensation of sulfonamide and maleic anhydride derivatives. The Dawson heteropolyacid was used with a catalytic amount of 2?mmol% in acetonitrile at reflux. The reuse of H6P2W18O62as heterogeneous catalyst several times without decrease in their activity, short reaction times, easy isolation of desired products with good to excellent yields shows the advantages of this novel methodology.

Synthesis of new substituted N-sulfonyl pyrrolidine-2,5-dione using dawson-type heteropolyacid as catalyst

The synthesis of new series of pyrrolidine-2,5-diones having sulfonamide moieties is described. These compounds are synthesized in good yield in three steps (carbamoylation-sulfamoylation, deprotection and condensation) using a catalytic amount of H6P2W18O62 in acetonitrile under refluxing conditions.