Methanesulfonamide, N-[4-(4-piperidinylcarbonyl)phenyl]-,hydrochloride (1:1)

Base Information

• Chemical Name: Methanesulfonamide, N-[4-(4-piperidinylcarbonyl)phenyl]-,hydrochloride (1:1)
• CAS No.: 113559-02-7
• Molecular Formula: C13H18 N2 O3 S . Cl H
• Molecular Weight: 318.824
• Mol file: 113559-02-7.mol

Synonyms:Methanesulfonamide, N-[4-(4-piperidinylcarbonyl)phenyl]-, monohydrochloride (9CI)

Chemical Property of Methanesulfonamide, N-[4-(4-piperidinylcarbonyl)phenyl]-,hydrochloride (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonamide, N-[4-(4-piperidinylcarbonyl)phenyl]-,hydrochloride (1:1)

There total 4 articles about Methanesulfonamide, N-[4-(4-piperidinylcarbonyl)phenyl]-,hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-acetyl-4-(4-methylsulfonylaminobenzoyl)piperidine (113558-94-4) → N-[4-(4-piperidinyl-carbonyl)phenyl]-methanesulfonamide monohydrochloride (113559-02-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00165a003

Reference yield:

4-chloro-carbonyl piperidine hydrochloride + N-phenylmethanesulfonamide (1197-22-4) + 1,1,2,2-tetrachloroethane (79-34-5) → N-[4-(4-piperidinyl-carbonyl)phenyl]-methanesulfonamide monohydrochloride (113559-02-7)

Guidance literature:

AlCl₃; In sulfur dioxide; water;

Reference yield:

N-phenylmethanesulfonamide (1197-22-4) → N-[4-(4-piperidinyl-carbonyl)phenyl]-methanesulfonamide monohydrochloride (113559-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / AlCl₃ / CH₂Cl₂

2: 84 percent / 3 N HCl

With hydrogenchloride; aluminium trichloride; In dichloromethane;

DOI:10.1021/jm00165a003

upstream raw materials:

1-acetyl-4-(4-methylsulfonylaminobenzoyl)piperidine

N-phenylmethanesulfonamide

1,1,2,2-tetrachloroethane

Downstream raw materials:

E-4031

4-(4-methylsulfonylaminobenzoyl)-1-[3-(pyridin-4-yl)propyl]piperidine

N-[4-[[1-[3-(4-nitrophenoxy)propyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide

N-[4-[[1-[3-[4-(1H-Imidazol-1-yl)phenoxy]propyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide