(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid
CAS No.:132622-98-1
Molecular Formula:C10H18 N2 O4
Molecular Weight:230.26100
Hs Code.:
European Community (EC) Number:899-557-8
DSSTox Substance ID:DTXSID00564612
Mol file:132622-98-1.mol

Synonyms:132622-98-1;(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid;(2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID;(2R,4R)-4-amino-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;(2R,4R)-4-Amino-1-(tert-butoxycarbonyl)-pyrrolidine-2-carboxylic acid;(2R,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;MFCD08704542;1,2-Pyrrolidinedicarboxylic acid, 4-amino-, 1-(1,1-dimethylethyl) ester, (2R,4R)-;SCHEMBL9637157;DTXSID00564612;AKOS015841280;CS-W004634;DS-13333;EN300-91229;A26640;Y10626;(4R)-4-Amino-1-(tert-butoxycarbonyl)-D-proline;(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid;J-501046;(2R,4R)-4-amino-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid;1,2-Pyrrolidinedicarboxylicacid,4-amino-,1-(1,1-dimethylethyl)ester,(2R,4R)-

Suppliers and Price of (2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid
100mg
$ 220.00

Medical Isotopes, Inc.
(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid 95+%
1 g
$ 1250.00

Matrix Scientific
(2R,4R)-4-Amino-1-(tert-butoxycarbonyl)-pyrrolidine-2-carboxylic acid 95%
1g
$ 745.00

Crysdot
(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid 95+%
1g
$ 412.00

Chemenu
(2R,4R)-4-Amino-1-(tert-butoxycarbonyl)-pyrrolidine-2-carboxylicacid 95%
1g
$ 389.00

American Custom Chemicals Corporation
(2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
1G
$ 1346.73

Ambeed
(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid 95+%
100mg
$ 108.00

Ambeed
(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid 95+%
1g
$ 344.00

Ambeed
(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid 95+%
250mg
$ 166.00

Alichem
(2R,4R)-1-Boc-4-amino-pyrrolidine-2-carboxylicacid
250mg
$ 152.87

Total 27 raw suppliers

Chemical Property of (2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid

Chemical Property:

Melting Point:263-264℃
Boiling Point:371.1±42.0 °C(Predicted)
PKA:3.65±0.20(Predicted)
PSA：92.86000
Density:1.232
LogP:1.04590
Storage Temp.:2-8°C
XLogP3:-2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:230.12665706
Heavy Atom Count:16
Complexity:298

Purity/Quality:

97% ^*data from raw suppliers

(2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)O)N
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H](C[C@@H]1C(=O)O)N

Technology Process of (2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid

There total 8 articles about (2R,4R)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 132622-97-0
2-benzyl 1-(tert-butyl) (2R,4R)-4-azidopyrrolidine-1,2-dicarboxylate

: 132622-98-1
(2R,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; under 5171.5 Torr;
DOI:10.1021/jo00009a016

Reference yield: 83.0%

: 132622-98-1
(2R,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Guidance literature:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 132622-98-1
(2R,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / N,N-diisopropylethylamine / dioxane

2: 74 percent / CBr₄, PPh₃ / CH₂Cl₂ / 18 h

3: NaN₃ / dimethylformamide / 55 °C

4: 83 percent / H₂ / 10percent Pd/C / H₂O; ethanol / 5171.5 Torr

With sodium azide; carbon tetrabromide; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00009a016