(S)-Tert-butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-Tert-butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate
CAS No.:274692-08-9
Molecular Formula:C₁₁H₂₂N₂O₂
Molecular Weight:214.308
Hs Code.:
DSSTox Substance ID:DTXSID80452609
Wikidata:Q72436949
Mol file:274692-08-9.mol

Synonyms:274692-08-9;(S)-TERT-BUTYL 3-(2-AMINOETHYL)PYRROLIDINE-1-CARBOXYLATE;Tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate;tert-Butyl (S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate;(s)-tert-butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate;SCHEMBL16469685;DTXSID80452609;JHHBMDKAYOQBBB-VIFPVBQESA-N;ZKA69208;MFCD12828827;AKOS015950928;(S)-1-Boc-3-(2-aminoethyl)pyrrolidine;AM100612;AS-43160;CS-0079127;A26527;EN300-7195099;(S)-t-Butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate;(S)-3-aminoethylpyrrolidine-1-carboxylic acid tert-butyl ester;(S)-tert-butyl 3-(2-Aminoethyl)pyrrolidine-1-carboxylate ee;1-Pyrrolidinecarboxylicacid,3-(2-aminoethyl)-,1,1-dimethylethyl ester,(3S)-

Suppliers and Price of (S)-Tert-butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate 95+%
100mg
$ 218.00

Crysdot
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate 95+%
250mg
$ 349.00

Crysdot
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate 95+%
1g
$ 871.00

Chemenu
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate 95%
1g
$ 823.00

Alichem
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate
250mg
$ 473.22

Alichem
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate
100mg
$ 239.80

Alichem
(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate
1g
$ 1229.82

Activate Scientific
(S)-tert-butyl 3-(2-Aminoethyl)pyrrolidine-1-carboxylate 95+% ee
1 g
$ 904.00

Total 7 raw suppliers

Chemical Property of (S)-Tert-butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate

Chemical Property:

Boiling Point:297.5±13.0 °C(Predicted)
PKA:10.42±0.10(Predicted)
PSA：55.56000
Density:1.029
LogP:2.23040
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:214.168127949
Heavy Atom Count:15
Complexity:223

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl3-(2-aminoethyl)pyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C1)CCN
Isomeric SMILES:CC(C)(C)OC(=O)N1CC[C@@H](C1)CCN

Technology Process of (S)-Tert-butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-Tert-butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.45%

: tert-butyl (3R)-3-(carbamoylmethyl)pyrrolidine-1-carboxylate

: 274692-08-9,1420537-04-7
tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 274692-07-8,142253-46-1
(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

: 274692-08-9,1420537-04-7
tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate

Guidance literature:: With ammonium acetate; hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; for 2h;
DOI:10.7164/antibiotics.54.1080

Reference yield:

: 274692-06-7
tert-butyl (S)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate

: 274692-08-9,1420537-04-7
tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 21.4 g / DBU / acetonitrile / 13 h / Heating

2: 6.91 g / H₂; ammonium acetate / PtO₂ / ethanol / 2 h / 20 °C

With ammonium acetate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; platinum(IV) oxide; In ethanol; acetonitrile;
DOI:10.7164/antibiotics.54.1080