(R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate
CAS No.:274692-07-8
Molecular Formula:C₁₁H₁₈N₂O₂
Molecular Weight:210.276
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90472171
Wikidata:Q82300963
Mol file:274692-07-8.mol

Synonyms:274692-07-8;(R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate;3(R)-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Tert-butyl (3R)-3-(cyanomethyl)pyrrolidine-1-carboxylate;(R)-3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;SCHEMBL15626878;DTXSID90472171;IPLBXZOFLWOERN-VIFPVBQESA-N;ZKA69207;MFCD06738466;AKOS016009701;AS-43159;CS-0005399;A876921;tert-butyl (R)-3-cyanomethylpyrrolidine-1-carboxylate;(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate

Suppliers and Price of (R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate
50mg
$ 130.00

J&W Pharmlab
3(R)-Cyanomethyl-pyrrolidine-1-carboxylicacidtert-butylester 97%
5g
$ 2998.00

Crysdot
(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate 95+%
250mg
$ 490.00

Crysdot
(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate 95+%
1g
$ 708.00

Chemenu
(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate 95%
1g
$ 505.00

American Custom Chemicals Corporation
1-PYRROLIDINECARBOXYLIC ACID, 3-(CYANOMETHYL)-, 1,1-DIMETHYLETHYL ESTER 95.00%
1G
$ 1164.24

American Custom Chemicals Corporation
1-PYRROLIDINECARBOXYLIC ACID, 3-(CYANOMETHYL)-, 1,1-DIMETHYLETHYL ESTER 95.00%
5G
$ 3019.75

AK Scientific
(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate
250mg
$ 717.00

Activate Scientific
3(R)-Cyanomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 97+% ee
1 g
$ 966.00

Total 10 raw suppliers

Chemical Property of (R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

Chemical Property:

Boiling Point:327.4±15.0 °C(Predicted)
PKA:-2.14±0.40(Predicted)
PSA：53.33000
Density:1.062±0.06 g/cm3(Predicted)
LogP:2.09498
Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:210.136827821
Heavy Atom Count:15
Complexity:285

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl3-(cyanomethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C1)CC#N
Isomeric SMILES:CC(C)(C)OC(=O)N1CC[C@@H](C1)CC#N

Technology Process of (R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

There total 5 articles about (R)-tert-Butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

: 773837-37-9
sodium cyanide

: 1391730-27-0,114214-70-9
tert-butyl (S)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate

: 274692-07-8,142253-46-1
(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

Guidance literature:: In dimethyl sulfoxide; at 90 ℃;

Reference yield:

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 274692-06-7
tert-butyl (S)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate

: 274692-07-8,142253-46-1
(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 13h; Heating;
DOI:10.7164/antibiotics.54.1080

Reference yield:

: 199174-24-8
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

: 274692-07-8,142253-46-1
(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: dimethyl sulfoxide / 90 °C

With triethylamine; In dichloromethane; dimethyl sulfoxide;