Technology Process of 2,4-dimethyl-3-benzoyl-6-carboxy-4,7-dihydro-7-oxopyrrolo<3,2-b>pyridine-1-acetic acid
There total 7 articles about 2,4-dimethyl-3-benzoyl-6-carboxy-4,7-dihydro-7-oxopyrrolo<3,2-b>pyridine-1-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: C2H5ONa / ethanol / 1) rt, 15 min, 2) reflux, 2 h
2: gl. acetic acid / ethanol / Heating
3: 1) 60percent NaH / 1) THF, rt, 10 min, 2) reflux, 30 h
4: 74 percent / Dowtherm A / 0.5 h / Heating
5: 1) CH3ONa / 1) DMF, rt, 15 min, 2) rt, 1 h
6: conc. HCl / 15 h / Heating
With
hydrogenchloride; diphenyl ether-biphenyl eutectic; sodium methylate; sodium ethanolate; sodium hydride; acetic acid;
In
ethanol;
DOI:10.1002/jhet.5570270508
- Guidance literature:
-
Multi-step reaction with 5 steps
1: gl. acetic acid / ethanol / Heating
2: 1) 60percent NaH / 1) THF, rt, 10 min, 2) reflux, 30 h
3: 74 percent / Dowtherm A / 0.5 h / Heating
4: 1) CH3ONa / 1) DMF, rt, 15 min, 2) rt, 1 h
5: conc. HCl / 15 h / Heating
With
hydrogenchloride; diphenyl ether-biphenyl eutectic; sodium methylate; sodium hydride; acetic acid;
In
ethanol;
DOI:10.1002/jhet.5570270508
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) NaHCO3 / 1) EtOH, rt, 10 min, 2) toluene, reflux, 2 h
2: C2H5ONa / ethanol / 1) rt, 15 min, 2) reflux, 2 h
3: gl. acetic acid / ethanol / Heating
4: 1) 60percent NaH / 1) THF, rt, 10 min, 2) reflux, 30 h
5: 74 percent / Dowtherm A / 0.5 h / Heating
6: 1) CH3ONa / 1) DMF, rt, 15 min, 2) rt, 1 h
7: conc. HCl / 15 h / Heating
With
hydrogenchloride; diphenyl ether-biphenyl eutectic; sodium methylate; sodium ethanolate; sodium hydride; sodium hydrogencarbonate; acetic acid;
In
ethanol;
DOI:10.1002/jhet.5570270508
