N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline
CAS No.:1384312-84-8
Molecular Formula:C₁₁H₁₄ClNO₂
Molecular Weight:228.683
Hs Code.:

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Chemical Property of N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline

Chemical Property:

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Technology Process of N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline

There total 1 articles about N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1384312-84-8
N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate / 13 h / 20 °C

2: water-d2 / tetrahydrofuran / 18 h / 40 °C

With water-d2; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ja303443m

Reference yield:

: 1384312-84-8
N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline

: 73183-34-3
bis(pinacol)diborane

: 1384313-14-7
C₁₇H₂₄⁽²⁾HBClNO₄

: 1384313-16-9
C₁₇H₂₄⁽²⁾HBClNO₄

Guidance literature:: With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; 4,4'-di-tert-butyl-2,2'-bipyridine; In tert-butyl methyl ether; at 50 ℃; for 13h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ja303443m

Reference yield:

: 1384312-84-8
N-(tert-butoxycarbonyl)-N-deuterio-3-chloroaniline

: 73183-34-3
bis(pinacol)diborane

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1384313-14-7
C₁₇H₂₄⁽²⁾HBClNO₄

Guidance literature:: With catalyst: (Ir(OMe)COD)2/4,4'-tBu₂-2,2'-bipyridine; In further solvent(s); protected aniline reacted with pinacolborane and B2(O2C2Me4)2 in tert-butyl methyl ether in the presence of Ir complex (2 mol.-%) and 4,4'-di-tert-butyl-2,2'-bipyridine (4 mol.-%) at 50°C; >95% of deuterated B compd. obtained;
DOI:10.1021/ja303443m