(R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Base Information

Chemical Name:(R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol
CAS No.:115369-30-7
Molecular Formula:C₅₅H₇₀O₁₂SSi
Molecular Weight:983.305
Hs Code.:

(R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Synonyms:

Suppliers and Price of (R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

There total 19 articles about (R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115369-25-0
(R)-1-Benzyloxy-4-phenylsulfanyl-butan-2-ol

: 115369-30-7
(R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: MCPBA / CH₂Cl₂ / 1 h / 0 °C

2: 40 percent / hydrogen / 25percent Pd/C / ethanol; acetic acid / 5 h / Ambient temperature

3: imidazole / dimethylformamide / 2 h / Ambient temperature

4: PPTS / CH₂Cl₂ / Ambient temperature

5: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 30 min.

With 1H-imidazole; n-butyllithium; hydrogen; pyridinium p-toluenesulfonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86916-7

Reference yield:

: 108-98-5
thiophenol

: 115369-30-7
(R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hydride / 1.) THF, DMF, 2.) THF, DMF, RT, 1 h

2: MCPBA / CH₂Cl₂ / 1 h / 0 °C

3: 40 percent / hydrogen / 25percent Pd/C / ethanol; acetic acid / 5 h / Ambient temperature

4: imidazole / dimethylformamide / 2 h / Ambient temperature

5: PPTS / CH₂Cl₂ / Ambient temperature

6: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 30 min.

With 1H-imidazole; n-butyllithium; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86916-7

Reference yield:

: 115369-26-1
(R)-4-Benzenesulfonyl-1-benzyloxy-butan-2-ol

: 115369-30-7
(R)-4-Benzenesulfonyl-1-((4aR,6R,7R,8S,8aR)-7-benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-7-(tert-butyl-diphenyl-silanyloxy)-6-(1-ethoxy-ethoxy)-heptan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / hydrogen / 25percent Pd/C / ethanol; acetic acid / 5 h / Ambient temperature

2: imidazole / dimethylformamide / 2 h / Ambient temperature

3: PPTS / CH₂Cl₂ / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 30 min.

With 1H-imidazole; n-butyllithium; hydrogen; pyridinium p-toluenesulfonate; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86916-7