Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol

Base Information

Chemical Name:Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol
CAS No.:257938-67-3
Molecular Formula:C16H23 N O4
Molecular Weight:293.363
Hs Code.:
Mol file:257938-67-3.mol

Synonyms:(3R,4R)-3-Hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylicacid tert-butyl ester; tert-Butyl(3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

Suppliers and Price of Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(3R,4R)-tert-Butyl3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate 95+%
1g
$ 353.00

American Custom Chemicals Corporation
BOC-4-(4-HYDROXYPHENYL)-(3S,4S)-3-PIPERIDINOL 95.00%
250MG
$ 657.30

American Custom Chemicals Corporation
BOC-4-(4-HYDROXYPHENYL)-(3S,4S)-3-PIPERIDINOL 95.00%
5MG
$ 498.23

Alichem
(3R,4R)-tert-Butyl3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate
1g
$ 400.00

Total 14 raw suppliers

Chemical Property of Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol

Chemical Property:

Boiling Point:451.6±45.0 °C(Predicted)
PKA:10.15±0.30(Predicted)
PSA：70.00000
Density:1.200±0.06 g/cm3(Predicted)
LogP:2.41540

Purity/Quality:

98% Min ^*data from raw suppliers

(3R,4R)-tert-Butyl3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol

There total 13 articles about Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

: tert-butyl (3S,4S)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate

: 257938-67-3
tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate

Guidance literature:: Resolution of racemate;

Reference yield:

: 357608-35-6
tert-butyl 4-[4-(tert-butyl-dimethyl-silanoxy)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate

: 257938-67-3
tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / AD-mix-α; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 - 20 °C

2: TBAF / tetrahydrofuran / 0 - 20 °C

3: 1.10 g / Raney Ni / ethanol / 4 h / Heating

With AD-mix-α; methanesulfonamide; tetrabutyl ammonium fluoride; nickel; In tetrahydrofuran; ethanol; water; tert-butyl alcohol; 1: Sharpless dihydroxylation;
DOI:10.1021/ol016092u

Reference yield:

: 357608-36-7
tert-butyl 4-[4-(tert-butyl-dimethyl-silanoxy)-phenyl]-3,4-dihydroxy-piperidine-1-carboxylate

: 257938-67-3
tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran / 0 - 20 °C

2: 1.10 g / Raney Ni / ethanol / 4 h / Heating

With tetrabutyl ammonium fluoride; nickel; In tetrahydrofuran; ethanol;
DOI:10.1021/ol016092u