(R)-3-methoxy-2-methylpropan-1-ol

Base Information

• Chemical Name: (R)-3-methoxy-2-methylpropan-1-ol
• CAS No.: 911855-78-2
• Molecular Formula: C5H12 O2
• Molecular Weight: 104.149
• Mol file: 911855-78-2.mol

Synonyms:(R)-3-Methoxy-2-methyl-1-propanol;(R)-3-Methoxy-2-methylpropan-1-ol

Chemical Property of (R)-3-methoxy-2-methylpropan-1-ol

Chemical Property:

• Boiling Point: 162oC
• PKA: 14.81±0.10(Predicted)
• Flash Point: 51oC
• PSA: 29.46000
• Density: 0.903
• LogP: 0.26120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-3-METHOXY-2-METHYLPROPAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-methoxy-2-methylpropan-1-ol

There total 4 articles about (R)-3-methoxy-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triisopropyl-(3-methoxy-2(S)-methyl-propoxy)-silane (912346-02-2) → (R)-3-methoxy-2-methyl-propan-1-ol (911855-78-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1 - 2h;

Reference yield:

(2S)-3-methoxy-2-methylpropanoic acid (10500-24-0) → (R)-3-methoxy-2-methyl-propan-1-ol (911855-78-2)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1039/jr9590000664

Reference yield:

3-methoxy-2-methyl propanoic acid (10500-24-0) → (R)-3-methoxy-2-methyl-propan-1-ol (911855-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: cinchonidine

2: lithium alanate; diethyl ether

With lithium aluminium tetrahydride; diethyl ether; Cinchonidin;

DOI:10.1039/jr9590000664

upstream raw materials:

(2S)-3-methoxy-2-methylpropanoic acid

triisopropyl-(3-methoxy-2(S)-methyl-propoxy)-silane

3-methoxy-2-methyl propanoic acid

Downstream raw materials:

6-[(3R,4R,5S)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

(rac-3R,4R,5S)-1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-trityloxymethyl-piperidin-3-ol

1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-3-(R,S)-trityloxy-methyl-piperidin-4-(R,S)-ol

1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxy-methyl)-phenyl]-3-(R,S)-trityloxymethyl-1,2,3,6-tetrahydro-pyridine

Refernces

• 1、 -. "SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS". Page/Page column 19; 23. . Retrieved 2009/10/30.
• 2、 -. "Bicyclic compounds". Page/Page column 11; 13. . Retrieved 2010/11/30.