10500-24-0

Upstream product

• 10500-20-6 β-methoxy-isobutyric acid butyl ester 
• 3852-11-7 3-methoxy-2-methylpropionic acid methyl ester 
• 21398-92-5 2-methoxymethyl-2-methyl malonic acid 
• 95757-42-9 methoxymethyl-methyl-malonic acid 
• 13141-08-7 β-methoxy-isobutyraldehyde 

Downstream Products

• 911855-78-2 (R)-3-methoxy-2-methyl-propan-1-ol 
• 3852-11-7 3-methoxy-2-methylpropionic acid methyl ester 
• 80-62-6 methacrylic acid methyl ester 
• 86177-97-1 N,N-Dimethylaminoethyl 2-methyl-3-methoxypropionate 

Relevant academic research and scientific papers

1-Aminopyridinium Ylides as Monodentate Directing Groups for sp3 C-H Bond Functionalization

1-Aminopyridinium ylides are efficient directing groups for palladium-catalyzed β-arylation and alkylation of sp3 C-H bonds in carboxylic acid derivatives. The efficiency of these directing groups depends on the substitution at the pyridine moiety. The unsubstituted pyridine-derived ylides allow functionalization of primary C-H bonds, while methylene groups are unreactive in the absence of external ligands. 4-Pyrrolidinopyridine-containing ylides are capable of C-H functionalization in acyclic methylene groups in the absence of external ligands, thus rivaling the efficiency of the aminoquinoline directing group. Preliminary mechanistic studies have been performed. A cyclopalladated intermediate has been isolated and characterized by X-ray crystallography, and its reactivity was studied.

CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS

Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR119. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

QUATERNARY SALTS OF N,N-DIMETHYLAMINOETHYL ESTERS OF PIVALIC AND 2-METHYL-3-METHOXYPROPIONIC ACID AND THEIR HYDROLYSIS

The synthesis and kinetics of quaternization of model compounds of poly(N,N-dimethylaminoethyl methacrylate) in water-alcoholic solutions brought about by methyl iodide and the alkaline hydrolysis of products in water have been investigated.N,N-Dimethylaminoethyl pivalate was selected as a model of the structural unit of the reported polymer; N,N-dimethylaminoethyl-2-methyl-3-methoxypropionate was the model of the terminal unit of the anionically prepared polymer.