2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Base Information

Chemical Name:2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
CAS No.:159780-01-5
Molecular Formula:C₂₂H₂₁F₃N₄O₅
Molecular Weight:478.428
Hs Code.:

2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Chemical Property of 2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Technology Process of 2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

There total 15 articles about 2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159780-62-8
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 159780-01-5
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: With dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; toluene; for 16h; Yield given; Ambient temperature;
DOI:10.1021/jm950684z

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 159780-01-5
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NMM, isobutyl chloroformate / 1.) THF, from -40 deg C to -20 deg C, 1.5 h, 2.) THF, RT, 1.5 h

2: 2,6-lutidine / tetrahydrofuran / 16 h / Ambient temperature

3: 81 percent / N₂H₄*H₂O / 3 h / Heating

4: 48 percent / 24 h / 120 °C / 1 Torr

5: 96 percent / LiI / pyridine / 14 h / Heating

6: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

7: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

8: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

9: dimethylformamide / 2.5 h / 120 °C

10: TBAF / tetrahydrofuran / 2 h / Ambient temperature

11: EDAC, 2,2-dichloroacetic acid / dimethylsulfoxide; toluene / 16 h / Ambient temperature

With 4-methyl-morpholine; 2,6-dimethylpyridine; dichloro-acetic acid; lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm950684z

Reference yield:

: 2397-26-4
N,N-dimethyl(chlorophenylmethylene)ammonium chloride

: 159780-01-5
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h

2: 48 percent / 24 h / 120 °C / 1 Torr

3: 96 percent / LiI / pyridine / 14 h / Heating

4: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

5: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

7: dimethylformamide / 2.5 h / 120 °C

8: TBAF / tetrahydrofuran / 2 h / Ambient temperature

9: EDAC, 2,2-dichloroacetic acid / dimethylsulfoxide; toluene / 16 h / Ambient temperature

With dichloro-acetic acid; lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm950684z