[4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester

Base Information

• Chemical Name: [4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester
• CAS No.: 207514-73-6
• Molecular Formula: C₄₄H₄₉N₃O₇
• Molecular Weight: 731.889
• Mol file: 207514-73-6.mol

Synonyms:

Chemical Property of [4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester

There total 1 articles about [4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5) → [4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester (207514-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: Et₃N / tetrahydrofuran / 6 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1248/cpb.46.452

Reference yield:

[4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester (207514-73-6) → H-t-AMCHA-Bpa-APAA trifluoroacetate

Guidance literature:

Multi-step reaction with 2 steps

1: anisole

2: H₂ / Pd/C

With hydrogen; methoxybenzene; palladium on activated charcoal;

DOI:10.1248/cpb.46.452

Reference yield:

trifluoroacetic acid (76-05-1) + [4-((S)-3-(4-Benzoyl-phenyl)-2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-propionylamino)-phenyl]-acetic acid benzyl ester (207514-73-6) → {4-[(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-3-(4-benzoyl-phenyl)-propionylamino]-phenyl}-acetic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:

With methoxybenzene;

DOI:10.1248/cpb.46.452

upstream raw materials:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid