(Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

Base Information

Chemical Name:(Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester
CAS No.:143006-18-2
Molecular Formula:C₂₈H₃₅N₂O₈P
Molecular Weight:558.568
Hs Code.:

(Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

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Chemical Property of (Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

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Technology Process of (Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

There total 11 articles about (Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(2R,3S)-2-[2-(2-Acetoxymethyl-[1,3]dioxolan-2-yl)-ethyl]-3-((S)-2,2-dimethyl-4-phenyl-oxazolidin-3-yl)-4-oxo-azetidin-1-yl]-(diethoxy-phosphoryl)-acetic acid benzyl ester

: 143006-18-2
(Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

Guidance literature:: With sulfuric acid; acetic acid; at 50 ℃; for 2.5h;
DOI:10.1021/jo00046a030

Reference yield:

: 52039-22-2
benzyl α-amino(diethylphosphono)acetate

: 143006-18-2
(Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: MgSO₄ / diethyl ether / 0.67 h / Ambient temperature

2: 32 percent / CH₂Cl₂ / 44 h / Irradiation

3: 11 mg / 10percent H₂SO₄, AcOH / 2.5 h / 50 °C

With sulfuric acid; magnesium sulfate; acetic acid; In diethyl ether; dichloromethane;
DOI:10.1021/jo00046a030

Reference yield:

: 54244-69-8
tert-butoxycarbonylamino-acetic acid benzyl ester

: 143006-18-2
(Diethoxy-phosphoryl)-((2aR,7S,7bS)-4a-hydroxymethyl-1-oxo-7-phenyl-octahydro-5-oxa-2,7a-diaza-cyclobuta[e]inden-2-yl)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / N-bromosuccinimide / CCl₄ / 15 °C / Irradiation

2: 61 percent / CH₂Cl₂ / Ambient temperature

3: 85 percent / HCl (gas) / CH₂Cl₂ / Ambient temperature

4: MgSO₄ / diethyl ether / 0.67 h / Ambient temperature

5: 32 percent / CH₂Cl₂ / 44 h / Irradiation

6: 11 mg / 10percent H₂SO₄, AcOH / 2.5 h / 50 °C

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; magnesium sulfate; acetic acid; In tetrachloromethane; diethyl ether; dichloromethane;
DOI:10.1021/jo00046a030