Ethyl N--L-phenylalaninate

Base Information

Chemical Name:Ethyl N--L-phenylalaninate
CAS No.:136583-44-3
Molecular Formula:C₃₃H₃₆N₂O₄
Molecular Weight:524.66
Hs Code.:

Ethyl N-<N-Acetyl-2,2-bis(3-phenylprop-2-en-1-yl)glycyl>-L-phenylalaninate

Synonyms:

Suppliers and Price of Ethyl N--L-phenylalaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl N--L-phenylalaninate

Chemical Property:

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Technology Process of Ethyl N--L-phenylalaninate

There total 5 articles about Ethyl N--L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 108-24-7
acetic anhydride

: 136604-26-7
Ethyl N-<2-Nitro-2,2-bis(3-phenylprop-2-en-1-yl)acetyl>-L-phenylalaninate

: 136583-44-3
Ethyl N--L-phenylalaninate

Guidance literature:: With acetic acid; zinc; at 40 - 60 ℃;
DOI:10.1002/hlca.19910740516

Reference yield:

: 3081-24-1
H-Phe-OEt

: 136583-44-3
Ethyl N--L-phenylalaninate

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / TsOH / acetonitrile / 30 - 80 °C

2: 90 percent / HgCl₂ / acetonitrile; H₂O / 30 °C

3: 1) 1,8-diazabicyclo<5.4.0>undec-7-ene, bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / 1) MeCN, 5 min; 2) MeCN, 25-30 deg C, 8-10 h

4: 44 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / acetonitrile / 10 h

5: 51 percent / Zn, HOAc / 40 - 60 °C

With toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; mercury dichloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; acetonitrile;
DOI:10.1002/hlca.19910740516

Reference yield:

: 136583-21-6
N-Nitroacetyl-(S)-phenylalanine ethyl ester

: 136583-44-3
Ethyl N--L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 1,8-diazabicyclo<5.4.0>undec-7-ene, bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / 1) MeCN, 5 min; 2) MeCN, 25-30 deg C, 8-10 h

2: 44 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / bis(dibenzylidene)palladium⁽⁰⁾, PPh₃ / acetonitrile / 10 h

3: 51 percent / Zn, HOAc / 40 - 60 °C

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile;
DOI:10.1002/hlca.19910740516