Technology Process of benzyl 2-(6-(carbamoyloxy)-1-hydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)sulfamoyl
There total 7 articles about benzyl 2-(6-(carbamoyloxy)-1-hydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)sulfamoyl which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridinium p-toluenesulfonate / dichloromethane / 18 h / 20 °C
2.1: pyridine / dichloromethane / 3 h / -10 - 0 °C
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere
4.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 20 - 55 °C
4.2: 1.5 h / -78 - 20 °C
4.3: 20 °C
5.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 - 20 °C
6.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C
6.2: pH 2
7.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
8.1: water / acetonitrile / 0.5 h / 0 °C
8.2: 1 h / 0 - 20 °C
With
pyridine; hydrogenchloride; chloro-trimethyl-silane; water; potassium acetate; lithium hydroxide; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine / dichloromethane / 3 h / -10 - 0 °C
2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere
3.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 20 - 55 °C
3.2: 1.5 h / -78 - 20 °C
3.3: 20 °C
4.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 - 20 °C
5.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C
5.2: pH 2
6.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
7.1: water / acetonitrile / 0.5 h / 0 °C
7.2: 1 h / 0 - 20 °C
With
pyridine; hydrogenchloride; chloro-trimethyl-silane; water; potassium acetate; lithium hydroxide; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere
2.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 20 - 55 °C
2.2: 1.5 h / -78 - 20 °C
2.3: 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 - 20 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C
4.2: pH 2
5.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
6.1: water / acetonitrile / 0.5 h / 0 °C
6.2: 1 h / 0 - 20 °C
With
hydrogenchloride; chloro-trimethyl-silane; water; potassium acetate; lithium hydroxide; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
