diethyl 2-(4-tert-butylphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate

Base Information

• Chemical Name: diethyl 2-(4-tert-butylphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
• CAS No.: 1005106-40-0
• Molecular Formula: C₂₃H₃₂O₆
• Molecular Weight: 404.503
• Mol file: 1005106-40-0.mol

Synonyms:

Chemical Property of diethyl 2-(4-tert-butylphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(4-tert-butylphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate

There total 1 articles about diethyl 2-(4-tert-butylphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-Butylbenzaldehyde (939-97-9) + ethyl acetoacetate (141-97-9) → C23H32O6 (1005106-40-0)

Guidance literature:

With piperidine; In ethanol; at 20 ℃; for 20h;

DOI:10.1021/jm2005892

Reference yield:

C23H32O6 (1005106-40-0) → 3-(4-t-butylphenyl)-4-(5-iodo-2-benzimidazolyl)butanoic acid hydrochloride (1221962-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / 2 h / Reflux

1.2: Cooling with ice

2.1: acetyl chloride / 2 h / Reflux

3.1: dichloromethane / 1 h / 20 °C

3.2: 1.5 h / Reflux

With acetyl chloride; sodium hydroxide; In dichloromethane;

DOI:10.1021/jm2005892

Reference yield:

C23H32O6 (1005106-40-0) → 3-(4-tert-butylphenyl)glutaric diacid (185049-53-0)

Guidance literature:

C₂₃H₃₂O₆; With sodium hydroxide; for 2h; Reflux;

With hydrogenchloride; In water; Cooling with ice;

DOI:10.1021/jm2005892

upstream raw materials:

4-tert-Butylbenzaldehyde

ethyl acetoacetate

Downstream raw materials:

3-(4-t-butylphenyl)-4-(5-iodo-2-benzimidazolyl)butanoic acid hydrochloride

3-(4-tert-butylphenyl)glutaric anhydride

3-(4-tert-butylphenyl)glutaric diacid

Refernces