Technology Process of 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(5,6,7,8-tetrahydroquinolin-8-ylamino)pyrimidin-5-carboxamide
There total 4 articles about 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(5,6,7,8-tetrahydroquinolin-8-ylamino)pyrimidin-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h
1.2: 2 h
2.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C
2.2: 1.5 h / 90 °C
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid;
In
1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / 1,4-dioxane; water
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h
2.2: 2 h
3.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C
3.2: 1.5 h / 90 °C
With
lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium phosphate; copper(l) iodide; ethylenediamine / dimethyl sulfoxide; 1,4-dioxane / 72 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 40 °C
3.1: lithium hydroxide monohydrate / 1,4-dioxane; water
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h
4.2: 2 h
5.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C
5.2: 1.5 h / 90 °C
With
potassium phosphate; copper(l) iodide; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethylenediamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
