(3,4-Difluorophenyl)hydrazine

Base Information

• Chemical Name: (3,4-Difluorophenyl)hydrazine
• CAS No.: 161886-22-2
• Molecular Formula: C6H6F2N2
• Molecular Weight: 144.124
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID90378942
• Nikkaji Number: J2.342.245J
• Wikidata: Q82168546
• Mol file: 161886-22-2.mol

Synonyms:(3,4-difluorophenyl)hydrazine;161886-22-2;3,4-Difluorophenylhydrazine;(3,4-Difluoro-phenyl)-hydrazine;Hydrazine, (3,4-difluorophenyl)-;Hydrazine,(3,4-difluorophenyl)-;3,4-difluoro phenylhydrazine;3,4-difluoro-phenylhydrazine;? 3,4-Difluorophenylhydrazine;SCHEMBL1143594;DTXSID90378942;1-(3,4-Difluorophenyl)hydrazine;KBSCNXDDCDSLLP-UHFFFAOYSA-N;AMY14527;MFCD03788477;AKOS000162773;SB34053;1,2-DIFLUORO-4-HYDRAZINOBENZENE;BB 0219221;CS-0268928;FT-0643564;EN300-261205;F12482;A810303

Chemical Property of (3,4-Difluorophenyl)hydrazine

Chemical Property:

• Vapor Pressure: 0.19mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 210.7 °C at 760 mmHg
• PKA: 5.10±0.24(Predicted)
• Flash Point: 81.2 °C
• PSA: 38.05000
• Density: 1.379 g/cm³
• LogP: 2.02370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 144.04990452
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

(3,4-Difluoro-phenyl)-hydrazine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NN)F)F

Technology Process of (3,4-Difluorophenyl)hydrazine

There total 3 articles about (3,4-Difluorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ 3,4-difluorophenyl hydrazine (161886-22-2)

Guidance literature:

Reference yield: 57.5%

3,4-difluoroaniline (3863-11-4) → 3,4-difluorophenyl hydrazine (161886-22-2)

Guidance literature:

3,4-difluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1.16667h;

With tin(ll) chloride; In water; at 0 ℃;

Reference yield: 57.4%

stannous chloride (7772-99-8) + 3,4-difluoroaniline (3863-11-4) → 3,4-difluorophenyl hydrazine (161886-22-2)

Guidance literature:

With sodium nitrite; In hydrogenchloride; water;

upstream raw materials:

3,4-difluoroaniline

stannous chloride

Refernces

• 1、 -. "Pyrazole compound and application thereof". Paragraph 0230; 0233-0235; 0299; 0301-0303. . Retrieved 2021/03/31.
• 2、 -. "RENIN INHIBITORS". Page/Page column 127. . Retrieved 2010/11/17.