5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE(MINIMUM90%)

Base Information

• Chemical Name: 5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE(MINIMUM90%)
• CAS No.: 909649-06-5
• Molecular Formula: C8H4BrClN2
• Molecular Weight: 243.49
• Hs Code.: 2933990090
• Mol file: 909649-06-5.mol

Synonyms:1,7-Naphthyridine, 5-bromo-8-chloro-;

Chemical Property of 5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE(MINIMUM90%)

Chemical Property:

• Vapor Pressure: 0.00014mmHg at 25°C
• Refractive Index: 1.691
• Boiling Point: 343.5 °C at 760 mmHg
• PKA: -0.14±0.30(Predicted)
• Flash Point: 161.5 °C
• PSA: 25.78000
• Density: 1.762 g/cm³
• LogP: 3.04570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-8-chloro-1,7-naphthyridine 90+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE(MINIMUM90%)

There total 3 articles about 5-BROMO-8-CHLORO-1,7-NAPHTHYRIDINE(MINIMUM90%) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

8-amino-5-bromo-1,7-naphthyridine (67967-17-3) → 5-bromo-8-chloro-[1,7]naphthyridine (909649-06-5)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

Reference yield:

2,3-Diaminopyridine (452-58-4) → 5-bromo-8-chloro-[1,7]naphthyridine (909649-06-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium 3-nitrobenzenesulfonate; sulfuric acid / water / 36 h / 135 °C

2: bromine; acetic acid / 3 h / 90 °C

3: sodium nitrite; hydrogenchloride / water / -10 °C

With hydrogenchloride; sulfuric acid; bromine; acetic acid; sodium 3-nitrobenzenesulfonate; sodium nitrite; In water;

Reference yield:

8-amino-1,7-naphthyridine (17965-82-1) → 5-bromo-8-chloro-[1,7]naphthyridine (909649-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / 3 h / 90 °C

2: sodium nitrite; hydrogenchloride / water / -10 °C

With hydrogenchloride; bromine; acetic acid; sodium nitrite; In water;

upstream raw materials:

8-amino-5-bromo-1,7-naphthyridine

2,3-Diaminopyridine

8-amino-1,7-naphthyridine

Downstream raw materials:

5-bromo-1,7-naphthyridine

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