1,7-Naphthyridin-8-amine

Base Information

• Chemical Name: 1,7-Naphthyridin-8-amine
• CAS No.: 17965-82-1
• Molecular Formula: C8H7N3
• Molecular Weight: 145.164
• Hs Code.: 2933990090
• European Community (EC) Number: 674-428-7
• DSSTox Substance ID: DTXSID90371791
• Nikkaji Number: J82.698G
• Wikidata: Q82159238
• Mol file: 17965-82-1.mol

Synonyms:1,7-naphthyridin-8-amine;17965-82-1;8-Amino-1,7-naphthyridine;[1,7]naphthyridin-8-ylamine;MFCD01319219;O72;Peakdale1_001027;SCHEMBL3042631;1,7-naphthyridin-8(7h)-imine;HMS520O15;DTXSID90371791;LRKLTZGZHDEBME-UHFFFAOYSA-N;AKOS002664172;AB08899;PS-3208;1,7-Naphthyridin-8-amine, AldrichCPR;AC-26740;SY062695;CS-0094697;FT-0602223;EN300-93380;A812470;Z3034935779

Chemical Property of 1,7-Naphthyridin-8-amine

Chemical Property:

• Vapor Pressure: 0.00907mmHg at 25°C
• Melting Point: 167-170 °C
• Refractive Index: 1.435
• Boiling Point: 343.301 °C at 760 mmHg
• PKA: 5.54±0.30(Predicted)
• Flash Point: 188.206 °C
• PSA: 51.80000
• Density: 1.293 g/cm³
• LogP: 1.79320
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 145.063997236
• Heavy Atom Count: 11
• Complexity: 137

Purity/Quality:

98%min ^*data from raw suppliers

1,7-Naphthyridin-8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-36-25
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=NC=C2)N)N=C1
• Uses: 1,7-Naphthyridin-8-amine is a useful chemical in organic synthesis.

Technology Process of 1,7-Naphthyridin-8-amine

There total 3 articles about 1,7-Naphthyridin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2,3-Diaminopyridine (452-58-4) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 8-amino-1,7-naphthyridine (17965-82-1)

Guidance literature:

2,3-Diaminopyridine; glycerol; With sulfuric acid; sodium 3-nitrobenzenesulfonate; In water; at 135 ℃; for 16h;

With sodium hydroxide; In water; pH=~ 9;

Reference yield:

[1,7]naphthyridine (253-69-0) → 4-amino-1,7-naphthyridine (58680-41-4) + 2-amino-1,7-naphthyridine (54920-84-2) + 8-amino-1,7-naphthyridine (17965-82-1)

Guidance literature:

With potassium permanganate; potassium amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) NH₃ (liquid), -40 deg C, 10 min, 2.) 10 min;

DOI:10.1021/jo00323a031

Reference yield:

→ 8-amino-1,7-naphthyridine (17965-82-1)

Guidance literature:

5-Brom-1,7-naphthyridin, KNH2/NH3; neben 3 u. 17;

upstream raw materials:

[1,7]naphthyridine

2,3-Diaminopyridine

glycerol

Downstream raw materials:

1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine

C₁₇H₁₃N₃O₂S

7-benzenesulfonyl-6-methylsulfanyl-4,5,8atriaza-phenanthren-8-ylideneamine monotrifluoroacetate

5-bromo-8-chloro-[1,7]naphthyridine

Refernces

• 1、 -. "HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME". Paragraph 00301-00303. . Retrieved 2019/04/16.
• 2、 -. "1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS". Paragraph 0278. . Retrieved 2017/02/09.