2,4-DIBROMOQUINAZOLINE

Base Information

• Chemical Name: 2,4-DIBROMOQUINAZOLINE
• CAS No.: 872998-61-3
• Molecular Formula: C8H4Br2N2
• Molecular Weight: 287.941
• Hs Code.: 2933990090
• Mol file: 872998-61-3.mol

Synonyms:2,4-Dibromoquinazoline;

Chemical Property of 2,4-DIBROMOQUINAZOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.71
• Boiling Point: 406.583 °C at 760 mmHg
• PKA: -0.46±0.30(Predicted)
• Flash Point: 199.695 °C
• PSA: 25.78000
• Density: 2.023g/cm³
• LogP: 3.15480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dibromoquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIBROMOQUINAZOLINE

There total 2 articles about 2,4-DIBROMOQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2,4-quinazoline dione → 2,4-dibromoquinazoline (872998-61-3)

Guidance literature:

With N,N-dimethyl-aniline; phosphorus(V) oxybromide; at 110 ℃; for 4h;

DOI:10.1021/jm1008902

Reference yield: 52.0%

1,2,3,4-tetrahydro-quinazoline-2,4-dione (86-96-4) → 2,4-dibromoquinazoline (872998-61-3)

Guidance literature:

With N,N-dimethyl-aniline; phosphorus(V) oxybromide; at 105 ℃; for 4h;

DOI:10.1055/s-2005-918923

Reference yield: 100.0%

2,4-dibromoquinazoline (872998-61-3) → 2-bromoquinazolin-4(3H)-one (872998-62-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1055/s-2005-918923

upstream raw materials:

1,2,3,4-tetrahydro-quinazoline-2,4-dione

Downstream raw materials:

2-bromoquinazolin-4(3H)-one

2-bromo-3-propynylquinazolin-4(3H)-one

2-bromo-3-pent-2-ynyl-3H-quinazolin-4-one

2-bromo-3-(5-trimethylsilanyl-pent-2-ynyl)-3H-quinazolin-4-one

Refernces

• 1、 Tangirala, Raghuraman,Antony, Smitha,Agama, Keli,Pommier, Yves,Curran, Dennis P.. "Total synthesis of luotonin and a small library of AB-ring substituted analogues by cascade radical annulation of isonitriles". . p. 2843 - 2846. Retrieved 2007/10/03.