SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE

Base Information

• Chemical Name: SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE
• CAS No.: 300552-38-9
• Molecular Formula: C₁₃H₁₄ClNO₂*ClH
• Molecular Weight: 288.174
• Hs Code.: 2934999090
• Mol file: 300552-38-9.mol

Synonyms:Spiro[2H-1-benzopyran-2,4'-piperidin]-4(3H)-one,6-chloro-, hydrochloride (9CI);6-Chlorospiro[chromene-2,4'-piperidin]-4(3H)-one hydrochloride;

Chemical Property of SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE

Chemical Property:

• Boiling Point: 448.4 °C at 760 mmHg
• Flash Point: 225 °C
• PSA: 38.33000
• Density: 1.32g/cm3
• LogP: 2.75620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Chlorospiro[chroman-2,4'-piperidin]-4-one hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE

There total 5 articles about SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO-, HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbonochloridic acid 1-chloro-ethyl ester (50893-53-3) + 1'-benzyl-6-chlorospiro[chromene-2,4'-piperidin]-4(3H)-one (81122-68-1) → 6-chloro-spiro[chroman-2,4'-piperidin]-4-one hydrochloride (300552-38-9)

Guidance literature:

In methanol; acetone;

Reference yield:

N-Boc-6-chlorospiro[chromene-2,4'-piperidin]-4(3H)-one (1011482-37-3) → 6-chloro-spiro[chroman-2,4'-piperidin]-4-one hydrochloride (300552-38-9)

Guidance literature:

With hydrogenchloride; water; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1021/acs.jafc.9b07055

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 6-chloro-spiro[chroman-2,4'-piperidin]-4-one hydrochloride (300552-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyrrolidine / methanol / 70 °C

2: hydrogenchloride; water / ethyl acetate / 2 h / 20 °C

With pyrrolidine; hydrogenchloride; water; In methanol; ethyl acetate;

DOI:10.1021/acs.jafc.9b07055

upstream raw materials:

carbonochloridic acid 1-chloro-ethyl ester

1'-benzyl-6-chlorospiro[chromene-2,4'-piperidin]-4(3H)-one

N-tert-butyloxycarbonylpiperidin-4-one

5-chloro-2-hydroxyacetophenone

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