tert-Butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Base Information

• Chemical Name: tert-Butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
• CAS No.: 192869-49-1
• Molecular Formula: C₁₂H₁₇N₃O₂
• Molecular Weight: 235.286
• Hs Code.: 2933990090
• Mol file: 192869-49-1.mol

Synonyms:tert-butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate;

Chemical Property of tert-Butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.539
• Boiling Point: 361.17 °C at 760 mmHg
• PKA: 2.09±0.20(Predicted)
• Flash Point: 172.23 °C
• PSA: 55.32000
• Density: 1.171 g/cm³
• LogP: 1.70770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

There total 4 articles about tert-Butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (1202645-17-7) + formamidine acetic acid (3473-63-0) → tert-butyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylate (192869-49-1)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield: 65.0%

→ tert-butyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylate (192869-49-1)

Guidance literature:

Reference yield:

(Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester (1310796-19-0,1202645-17-7) → tert-butyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-carboxylate (192869-49-1)

Guidance literature:

formamidine acetic acid; With sodium ethanolate; In ethanol; for 0.5h; Heating / reflux;

(Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester; for 18h;

upstream raw materials:

(Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester

3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

formamidine acetic acid

N-tert-butyloxycarbonylpiperidin-4-one