2,3-Dihydro-2-phenyl-4(1H)-quinolinone

Base Information

• Chemical Name: 2,3-Dihydro-2-phenyl-4(1H)-quinolinone
• CAS No.: 16619-14-0
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID301317867
• Nikkaji Number: J312.856C
• Metabolomics Workbench ID: 144602
• ChEMBL ID: CHEMBL440091
• Mol file: 16619-14-0.mol

Synonyms:16619-14-0;2,3-Dihydro-2-phenyl-4(1H)-quinolinone;2-Phenyl-2,3-dihydroquinolin-4(1H)-one;113567-29-6;2-PHENYL-2,3-DIHYDRO-4-QUINOLONE;Aza-flavanone;2-phenyl-2,3-dihydro-1H-quinolin-4-one;Azaflavanone;2-phenyl-2,3-dihydro-4(1H)-quinolinone;(2R)-2-Phenyl-2,3-dihydro-4-quinolone;2-phenyl-1,2,3,4-tetrahydroquinolin-4-one;CHEMBL440091;SCHEMBL1501991;PUCZUBFZQVSURB-UHFFFAOYSA-N;DTXSID301317867;BDBM50472200;AKOS015840567;FS-2774;SB47577;SB47578;2,3-dihydro-2-phenyl-4(1h)-quinolone;2-Phenyl-1,2-dihydroquinolin-4(3H)-one;FT-0645902;FT-0743203;A882345

Chemical Property of 2,3-Dihydro-2-phenyl-4(1H)-quinolinone

Chemical Property:

• Vapor Pressure: 6.2E-07mmHg at 25°C
• Melting Point: 149 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.603
• Boiling Point: 410.1 °C at 760 mmHg
• PKA: 1.92±0.40(Predicted)
• Flash Point: 169 °C
• PSA: 29.10000
• Density: 1.156 g/cm³
• LogP: 3.56420
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 283

Purity/Quality:

97% ^*data from raw suppliers

2-Phenyl-2,3-dihydroquinolin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NC2=CC=CC=C2C1=O)C3=CC=CC=C3

Technology Process of 2,3-Dihydro-2-phenyl-4(1H)-quinolinone

There total 55 articles about 2,3-Dihydro-2-phenyl-4(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(2-aminophenyl)-3-phenylprop-2-en-1-one (78396-00-6) → 2-phenyl-2,3-dihydro-1H-quinolin-4-one (16619-14-0)

Guidance literature:

With antimony(III) chloride; In acetonitrile; at 55 ℃; for 3h;

DOI:10.1080/00397910902985523

Reference yield: 97.0%

(2E)-1-(2-nitrophenyl)-3-phenyl-2-propen-1-one (53744-32-4) → 2-phenyl-2,3-dihydro-1H-quinolin-4-one (16619-14-0)

Guidance literature:

(2E)-1-(2-nitrophenyl)-3-phenyl-2-propen-1-one; With hydrogen; In toluene; at 70 ℃; for 0.666667h; under 6750.68 Torr;

In toluene; at 100 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1002/cctc.201501403

Reference yield: 96.0%

2-Phenyl-4-triisopropylsilanyloxy-2H-quinoline-1-carboxylic acid benzyl ester (188987-98-6) → 2-phenyl-2,3-dihydro-1H-quinolin-4-one (16619-14-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1055/s-1997-758

upstream raw materials:

2-aminochalcone

sodium ethanolate

[E]-3-phenyl-1-(2-acetamidophenyl)prop-2-en-1-one

(2E)-1-(2-nitrophenyl)-3-phenyl-2-propen-1-one

Downstream raw materials:

4-Acetoxy-1-acetyl-1,2-dihydro-2-phenylquinoline

1-N-acetyl-4-keto-2-phenyl-1,2,3,4-tetrahydroquinoline

<1,2,3,4-tetrahydro-2-phenylquinolin-4-one> thiosemicarbazone

2-Oxo-2-{N'-[(R)-2-phenyl-2,3-dihydro-1H-quinolin-(4E)-ylidene]-hydrazino}-N-(1-phenyl-ethyl)-acetamide