tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1450789-80-6
Molecular Formula:C₄₄H₅₂N₆O₉S
Molecular Weight:840.998
Hs Code.:

tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Property of tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 10 articles about tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: C₃₃H₃₃N₅O₆S*ClH

: 1450789-80-6
tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

: 1450789-91-9
tert-butyl ((S)-1-(((R)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; pH=> 10;
DOI:10.1021/ml400217r

Reference yield:

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

: 1450789-80-6
tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

: 1450789-91-9
tert-butyl ((S)-1-(((R)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 45 °C / pH > 10

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C / pH > 10

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml400217r

Reference yield:

: C₁₅H₁₇N₃O₃

: 1450789-80-6
tert-butyl ((S)-1-(((S)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

: 1450789-91-9
tert-butyl ((S)-1-(((R)-1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((4-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 72 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 45 °C / pH > 10

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C / pH > 10

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml400217r