1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one

Base Information

• Chemical Name: 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one
• CAS No.: 144396-32-7
• Molecular Formula: C₆₀H₈₂O₆Si₂
• Molecular Weight: 955.478

Synonyms:

Chemical Property of 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one

There total 2 articles about 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol (144396-31-6,144490-20-0) → (2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanone (144396-33-8) + 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one (144396-32-7,144490-21-1)

Guidance literature:

With hexacarbonyl molybdenum; water; In acetonitrile;

DOI:10.1016/S0040-4039(00)61222-4

Reference yield:

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol (144396-30-5) → 1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one (144396-32-7,144490-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / PhNCO / toluene

2: 36 percent / Mo(CO)6, H₂O / acetonitrile

With hexacarbonyl molybdenum; water; phenyl isocyanate; In toluene; acetonitrile;

DOI:10.1016/S0040-4039(00)61222-4

Reference yield: 100.0%

1-{(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexyl}-propan-2-one (144396-32-7,144490-21-1) → (2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanone (144396-33-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)61222-4

upstream raw materials:

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(8R,10S)-8,10-Bis-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-en-(6E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

Downstream raw materials:

(2S,4R)-2,4-Bis-(tert-butyl-diphenyl-silanyloxy)-6-[2-[(1R,3aS,7aR)-1-[(S)-2-(2-hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-cyclohexanone

(1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(S)-2-(2-Hydroxy-2-methyl-propoxy)-1-methyl-ethyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethyl}-cyclohex-4-ene-1,3-diol

1-((S)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propoxy)-2-methyl-propan-2-ol

C₆₄H₈₄N₂O₆SSi₂

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