4,6-Dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile

Base Information

Chemical Name:4,6-Dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile
CAS No.:1679336-98-1
Molecular Formula:C₁₄H₁₃N₃OS
Molecular Weight:271.343
Hs Code.:
DSSTox Substance ID:DTXSID501120115
ChEMBL ID:CHEMBL3209074
Mol file:1679336-98-1.mol

Synonyms:4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile;1679336-98-1;MLS000538771;CHEMBL3209074;DVBIPPBYZQJRNM-LFIBNONCSA-N;DTXSID501120115;STK062603;AKOS000489039;4,6-dimethyl-2-oxo-1-[(E)-1-thiophen-2-ylethylideneamino]pyridine-3-carbonitrile;SMR000160534;AN-329/15538024;SR-01000082544;SR-01000082544-1;1,2-Dihydro-4,6-dimethyl-2-oxo-1-[(E)-[1-(2-thienyl)ethylidene]amino]-3-pyridinecarbonitrile;4,6-dimethyl-2-oxo-1-{[(1E)-1-(2-thienyl)ethylidene]amino}-1,2-dihydropyridine-3-carbonitrile;4,6-dimethyl-2-oxo-1-{[(1E)-1-(thiophen-2-yl)ethylidene]amino}-1,2-dihydropyridine-3-carbonitrile;4,6-dimethyl-2-oxo-1-{[(1E)-1-thien-2-ylethylidene]amino}-1,2-dihydropyridine-3-carbonitrile

Suppliers and Price of 4,6-Dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Aronis compounds
4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile
50mg
$ 50.00

Aronis compounds
4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile
5mg
$ 15.00

Total 0 raw suppliers

Chemical Property of 4,6-Dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:271.07793322
Heavy Atom Count:19
Complexity:550

Purity/Quality:: 4,6-dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C(=O)N1N=C(C)C2=CC=CS2)C#N)C
Isomeric SMILES:CC1=CC(=C(C(=O)N1/N=C(\C)/C2=CC=CS2)C#N)C

Technology Process of 4,6-Dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile

There total 2 articles about 4,6-Dimethyl-2-oxo-1-{[1-(2-thienyl)ethylidene]amino}-1,2-dihydro-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.5%

: 2-cyano-N'-(1-(thiophen-2-yl)ethylidene)acetohydrazide

: 123-54-6,81235-32-7
acetylacetone

: 1679336-98-1
1-(1-(thiophen-2-yl)ethylideneamino)-1,2-dihydro-4,6-dimethyl-2-oxopyridine-3-carbonitrile

Guidance literature:: With triethylamine; In ethanol; for 3h; Reflux;
DOI:10.1007/s00044-015-1353-5

Reference yield:

: 88-15-3,97511-16-5
2-Acetylthiophene

: 1679336-98-1
1-(1-(thiophen-2-yl)ethylideneamino)-1,2-dihydro-4,6-dimethyl-2-oxopyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 3 h / Reflux

2: triethylamine / ethanol / 3 h / Reflux

With triethylamine; In 1,4-dioxane; ethanol;
DOI:10.1007/s00044-015-1353-5