H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

Base Information

Chemical Name:H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH
CAS No.:145633-19-8
Molecular Formula:C₂HF₃O₂*C₅₄H₈₂N₁₀O₁₂
Molecular Weight:1177.33
Hs Code.:

H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF<sub>3</sub>COOH

Synonyms:

Suppliers and Price of H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

There total 13 articles about H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 90508-31-9
Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

: 145633-19-8
H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.166667h;
DOI:10.1002/jlac.198519850210

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 145633-19-8
H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NMM, isobutyl chloroformate; 2.) NMM / 1.) methylene dichloride, DMF, -20 deg C, 10 min 2.) -15 deg C, 1 h; -5 deg C, 1 h; than to RT

2: 92 percent / acetic acid, H₂ / Pd/C / methanol; H₂O / 5 h / 30 - 35 °C

3: 1.) HOBt, DCC 2.) NMM / 1.) DMF, 37-40 deg C, 15-20 min 2.) 37-40 deg C, 1 h; RT, 12 h; 0 deg C, 1 h

4: 90 percent / 1N NaOH / methanol / Ambient temperature

5: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 0 deg C, 30 min 2.) RT, 15 h

6: 73 percent / 1N NaOH / methanol / 4 h / 30 - 35 °C

7: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 37-40 deg C, 20 min; 2.) RT, 20 h

8: 71 percent / CF₃COOH / CH₂Cl₂ / 0.17 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1002/jlac.198519850210

Reference yield:

: 79118-23-3
Boc-Leu-Aib-OBzl

: 145633-19-8
H-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl*CF₃COOH

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / acetic acid, H₂ / Pd/C / methanol; H₂O / 5 h / 30 - 35 °C

2: 1.) HOBt, DCC 2.) NMM / 1.) DMF, 37-40 deg C, 15-20 min 2.) 37-40 deg C, 1 h; RT, 12 h; 0 deg C, 1 h

3: 90 percent / 1N NaOH / methanol / Ambient temperature

4: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 0 deg C, 30 min 2.) RT, 15 h

5: 73 percent / 1N NaOH / methanol / 4 h / 30 - 35 °C

6: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 37-40 deg C, 20 min; 2.) RT, 20 h

7: 71 percent / CF₃COOH / CH₂Cl₂ / 0.17 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1002/jlac.198519850210