2-BROMO-6-MORPHOLINOPYRAZINE

Base Information

• Chemical Name: 2-BROMO-6-MORPHOLINOPYRAZINE
• CAS No.: 848841-62-3
• Molecular Formula: C₈H₁₀BrN₃O
• Molecular Weight: 244.091
• Hs Code.: 2934999090
• Mol file: 848841-62-3.mol

Synonyms:Morpholine,4-(6-bromopyrazinyl)- (9CI);4-(6-Bromopyrazin-2-yl)morpholine;

Chemical Property of 2-BROMO-6-MORPHOLINOPYRAZINE

Chemical Property:

• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.583
• Boiling Point: 368.3 °C at 760 mmHg
• Flash Point: 176.5 °C
• PSA: 38.25000
• Density: 1.57 g/cm³
• LogP: 1.14070
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-(6-Bromopyrazin-2-yl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-6-MORPHOLINOPYRAZINE

There total 2 articles about 2-BROMO-6-MORPHOLINOPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,6-dibromopyrazine (23229-25-6) + 4-(6-chloropyrazin-2-yl)morpholine → 4-(6-bromopyrazin-2-yl)morpholine (848841-62-3)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 80 ℃;

DOI:10.1055/s-0040-1719873

Reference yield:

morpholine (110-91-8,99108-56-2) + 2,6-dibromopyrazine (23229-25-6) → 4-(6-bromopyrazin-2-yl)morpholine (848841-62-3)

Guidance literature:

at 0 - 20 ℃; for 5h;

Reference yield:

4-(6-bromopyrazin-2-yl)morpholine (848841-62-3) → 2-benzyl-6-(6-morpholinopyrazin-2-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 20 - 60 °C

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1055/s-0040-1719873

upstream raw materials:

morpholine

2,6-dibromopyrazine

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