23229-25-6

Usage

Uses

2,6-Dibromopyrazine is used as a pharmaceutical intermediate.

InChI:InChI=1/C4H2Br2N2/c5-3-1-7-2-4(6)8-3/h1-2H

Upstream product

• 6270-63-9 pyrazin-2(1H)-one 
• 4774-15-6 2,6-dimethoxypyrazine 
• 4774-14-5 2,6-dichloropyrazine 
• 290-37-9 1,4-pyrazine 
• 56423-63-3 2-bromopyrazine 

Downstream Products

• 4774-15-6 2,6-dimethoxypyrazine 
• 33870-85-8 2,6-Diethoxypyrazin 
• 41536-80-5 2,6-Diaminopyrazine 
• 848841-62-3 4-(6-bromopyrazin-2-yl)morpholine 
• 91678-76-1 2-bromo-6-methoxypyrazine 
• 54237-53-5 6-bromo-pyrazin-2-ylamine 

Relevant academic research and scientific papers

A method for synthesizing dibromo compounds

The present invention belongs to the field of synthesis technology of compounds, specifically disclosed a method of synthesis of dibromo compounds. The method of the present invention takes a dichloro compound as a raw material, first reacts with sodium methanol to form a dimethoxy compound, and then reacts with a bromination reagent to give a dibromo compound. The method of the present invention is not only mild reaction conditions, simple operation, and the reaction product is single, through simple post-treatment, and then the target product can be obtained at a high yield, it is expected to be developed as an industrial production method.

1,4-DISUBSTITUTED ISOQUINILONE DERIVATIVES AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES

This invention relates to compounds of formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.