2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

Base Information

Chemical Name:2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid
CAS No.:1306746-03-1
Molecular Formula:C₄₆H₅₀N₄O₈
Molecular Weight:786.925
Hs Code.:

2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

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Chemical Property of 2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

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Technology Process of 2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

There total 1 articles about 2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₀H₅₇N₄O₇Pol

: 1306746-03-1
2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In water; for 2h; solid phase reaction;
DOI:10.1021/jm200036n

Reference yield:

: 1306746-03-1
2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

: 1306746-16-6
2-(2-(((2S,6S,13S,E)-13-amino-2-(4-hydroxybenzyl)-4,14-dioxo-1,5-diazacyclotetradec-9-ene-6-carboxamido)methyl)phenyl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation; p-benzoquinone / 1,2-dichloro-ethane / 0.08 h / 120 °C / Microwave irradiation

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile / 0.5 h

With Hoveyda-Grubbs catalyst second generation; 1,8-diazabicyclo[5.4.0]undec-7-ene; p-benzoquinone; In dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200036n

Reference yield:

: 1306746-03-1
2-(2-((5S,8S,12S)-5,12-di(but-3-en-1-yl)-1-(9H-fluoren-9-yl)-8-(4-hydroxybenzyl)-3,6,10,13-tetraoxo-2-oxa-4,7,11,14-tetraazapentadecan-15-yl)phenyl)acetic acid

: 1306746-19-9
2-(2-(((2S,6S,13S,Z)-13-amino-2-(4-hydroxybenzyl)-4,14-dioxo-1,5-diazacyclotetradec-9-ene-6-carboxamido)methyl)phenyl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation; p-benzoquinone / 1,2-dichloro-ethane / 0.08 h / 120 °C / Microwave irradiation

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile / 0.5 h

With Hoveyda-Grubbs catalyst second generation; 1,8-diazabicyclo[5.4.0]undec-7-ene; p-benzoquinone; In dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200036n