(3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester

Base Information

Chemical Name:(3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester
CAS No.:1072449-84-3
Molecular Formula:C₁₃H₁₅NO₈
Molecular Weight:313.264
Hs Code.:
Mol file:1072449-84-3.mol

(3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester

Synonyms:

Suppliers and Price of (3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]methyl]-2-methyl-4H-pyrano[3,4-d]oxazole-6-carboxylicAcidMethylEster
50mg
$ 1260.00

Medical Isotopes, Inc.
(3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]methyl]-2-methyl-4H-pyrano[3,4-d]oxazole-6-carboxylicAcidMethylEster
5 mg
$ 650.00

Total 4 raw suppliers

Chemical Property of (3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester

Chemical Property:

Solubility.:Dimethylsulfoxide

Purity/Quality:

95% ^*data from raw suppliers

(3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]methyl]-2-methyl-4H-pyrano[3,4-d]oxazole-6-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]methyl]-2-methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester is an intermediate in the preparation of Neuraminic Acid and its derivatives.

Technology Process of (3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester

There total 1 articles about (3aR,4R,7aR)-3a,7a-Dihydro-4-[(S)-hydroxy[(4R)-2-oxo-1,3-dioxolan-4-yl]Methyl]-2-Methyl-4H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

: 1072449-83-2
methyl (3aS,4R,7aR)-4-[(1R,2R)-1,2,3-trihydroxy-propyl]-2-methyl-3a,7a-dihydro-4H-pyrano[3,4-d][1,3]oxazole-6-carboxylate

: 616-38-6
carbonic acid dimethyl ester

: 1072449-84-3
methyl (3aS,4R,7aR)-4-{(S)-hydroxy-((4R)-2-oxo-1,3-dioxolan-4-yl)methyl}-2-methyl-3a,7a-dihydro-4H-pyrano[3,4-d][1,3]oxazole-6-carboxylate

Guidance literature:: In methanol; at 25 - 55 ℃; for 6h; Product distribution / selectivity;

Reference yield:

: 1072449-84-3
methyl (3aS,4R,7aR)-4-{(S)-hydroxy-((4R)-2-oxo-1,3-dioxolan-4-yl)methyl}-2-methyl-3a,7a-dihydro-4H-pyrano[3,4-d][1,3]oxazole-6-carboxylate

: methyl (2R,3R,4S)-3-acetamide-4-azide-2-{(S)-methoxy[(4R)-2-oxo-1,3-dioxolan-4-yl]methyl}-3,4-dihydro-2H-pyran-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl acetamide; mineral oil / 3 h / 3 °C

2.1: titanium(IV) isopropylate; trimethylsilylazide / toluene; tert-butyl alcohol / 15 h / 18 °C

2.2: 1 h / 20 °C

With titanium(IV) isopropylate; trimethylsilylazide; sodium hydride; In tetrahydrofuran; N,N-dimethyl acetamide; toluene; mineral oil; tert-butyl alcohol;

Reference yield:

: 1072449-84-3
methyl (3aS,4R,7aR)-4-{(S)-hydroxy-((4R)-2-oxo-1,3-dioxolan-4-yl)methyl}-2-methyl-3a,7a-dihydro-4H-pyrano[3,4-d][1,3]oxazole-6-carboxylate

: 203120-17-6
Laninamivir

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl acetamide; mineral oil / 3 h / 3 °C

2.1: titanium(IV) isopropylate; trimethylsilylazide / toluene; tert-butyl alcohol / 15 h / 18 °C

2.2: 1 h / 20 °C

3.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 - 40 °C

3.2: 2 h / 40 °C

3.3: 25 °C

4.1: sodium hydroxide / water / pH 9.5

4.2: 46 h / 23 °C

5.1: hydrogenchloride / water / 4 h / 80 °C

With titanium(IV) isopropylate; hydrogenchloride; trimethylsilylazide; sodium hydride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water; toluene; mineral oil; tert-butyl alcohol;