6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester

Base Information

Chemical Name:6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester
CAS No.:410546-11-1
Molecular Formula:C₃₇H₅₉N₃O₁₀
Molecular Weight:705.89
Hs Code.:

6-[benzyl-(5-<i>tert</i>-butoxycarbonyl-5-<i>tert</i>-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-<i>tert</i>-butoxycarbonylamino-5-oxo-hexanoic acid <i>tert</i>-butyl ester

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Chemical Property of 6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester

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Technology Process of 6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester

There total 5 articles about 6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-46-9
benzylamine

: 220243-87-8
(S)-6-bromo-2-tert-butoxycarbonylamino-5-oxohexanoic acid tert-butyl ester

: 410546-11-1
6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 25 ℃; for 8h;
DOI:10.1039/b105478n

Reference yield:

: 24277-39-2
N-tert-butoxycarbonyl glutamic acid tert-butyl ester

: 410546-11-1
6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

2: 8.52 g / tetrahydrofuran; diethyl ether / 12 h / 0 °C

3: 65 percent / thymol blue; HBr; AcOH / tetrahydrofuran / -5 °C

4: K₂CO₃ / acetonitrile / 8 h / 25 °C

With 4-methyl-morpholine; hydrogen bromide; thymol blue; potassium carbonate; acetic acid; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1039/b105478n

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid tert-butyl ester

: 410546-11-1
6-[benzyl-(5-tert-butoxycarbonyl-5-tert-butoxycarbonylamino-2-oxo-pentyl)-amino]-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 8.52 g / tetrahydrofuran; diethyl ether / 12 h / 0 °C

2: 65 percent / thymol blue; HBr; AcOH / tetrahydrofuran / -5 °C

3: K₂CO₃ / acetonitrile / 8 h / 25 °C

With hydrogen bromide; thymol blue; potassium carbonate; acetic acid; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1039/b105478n