3-(trifluoromethyl)azetidin-3-ol hydrochloride

Base Information

• Chemical Name: 3-(trifluoromethyl)azetidin-3-ol hydrochloride
• CAS No.: 848192-96-1
• Molecular Formula: C4H6 F3 N O . Cl H
• Molecular Weight: 177.554
• Hs Code.: 2933998090
• Mol file: 848192-96-1.mol

Synonyms:3-Azetidinol,3-(trifluoromethyl)-, hydrochloride (9CI)

Chemical Property of 3-(trifluoromethyl)azetidin-3-ol hydrochloride

Chemical Property:

• PSA: 32.26000
• LogP: 1.01380
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(Trifluoromethyl)azetidin-3-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Trifluoromethyl)azetidin-3-ol Hydrochloride is used for benzoxaborole antimalarial agent.

Technology Process of 3-(trifluoromethyl)azetidin-3-ol hydrochloride

There total 3 articles about 3-(trifluoromethyl)azetidin-3-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-benzhydryl-3-(trifluoromethyl)azetidin-3-ol trifluoroacetate → 3-(trifluoromethyl)azetidin-3-ol hydrogen chloride (848192-96-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; palladium on carbon; In methanol; water; for 5h; under 2585.81 Torr;

Reference yield: 36.0%

→ 3-(trifluoromethyl)azetidin-3-ol hydrogen chloride (848192-96-1)

Guidance literature:

Reference yield:

1-benzhydryl-3-(trifluoromethyl)azetidin-3-ol (848192-92-7) → 3-(trifluoromethyl)azetidin-3-ol hydrogen chloride (848192-96-1)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.7b00621

upstream raw materials:

1-benzhydryl-3-(trifluoromethyl)azetidin-3-ol

Downstream raw materials:

2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(3-hydroxy-3-(trifluoromethyl)azetidin-1-yl)butan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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