homo-p-(R)-tyrosine

Base Information

• Chemical Name: homo-p-(R)-tyrosine
• CAS No.: 749828-81-7
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 749828-81-7.mol

Synonyms:homo-p-(R)-tyrosine

Chemical Property of homo-p-(R)-tyrosine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-Amino-4-(4-hydroxyphenyl)butanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of homo-p-(R)-tyrosine

There total 4 articles about homo-p-(R)-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C13H14F3NO4 (1263096-05-4) → homo-p-(R)-tyrosine (749828-81-7,185062-84-4)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 6h;

DOI:10.1016/j.tet.2010.11.047

Reference yield:

C13H12F3NO5 (1263096-01-0) → homo-p-(R)-tyrosine (749828-81-7,185062-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated carbon; hydrogen; acetic acid / 1 h / 20 °C

2: hydrogenchloride; water / 6 h / 80 °C

With hydrogenchloride; 10% palladium on activated carbon; water; hydrogen; acetic acid;

DOI:10.1016/j.tet.2010.11.047

Reference yield:

phenol (108-95-2,27073-41-2) → homo-p-(R)-tyrosine (749828-81-7,185062-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / 1 h / 0 - 20 °C

2: 10% palladium on activated carbon; hydrogen; acetic acid / 1 h / 20 °C

3: hydrogenchloride; water / 6 h / 80 °C

With hydrogenchloride; trifluorormethanesulfonic acid; 10% palladium on activated carbon; water; hydrogen; acetic acid; 1: Friedel-Crafts acylation;

DOI:10.1016/j.tet.2010.11.047

upstream raw materials:

C₁₃H₁₂F₃NO₅

C₁₃H₁₄F₃NO₄

phenol

Downstream raw materials:

(D)-(-)-methyl homotyrosinate

Boc-D-hTyr-OH