4-Amino-N-[3,5-bis(trifluoromethyl)phenyl]benzamide

Base Information

Chemical Name:4-Amino-N-[3,5-bis(trifluoromethyl)phenyl]benzamide
CAS No.:976-50-1
Molecular Formula:C₁₅H₁₀F₆N₂O
Molecular Weight:348.248
Hs Code.:
DSSTox Substance ID:DTXSID40697195
Wikidata:Q72438300
Mol file:976-50-1.mol

Synonyms:4-AMINO-N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]BENZAMIDE;976-50-1;DTXSID40697195;AKOS025125962;FT-0736857

Suppliers and Price of 4-Amino-N-[3,5-bis(trifluoromethyl)phenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 4-Amino-N-[3,5-bis(trifluoromethyl)phenyl]benzamide

Chemical Property:

PSA：55.12000
Density:1.465
LogP:5.21290
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:348.06973192
Heavy Atom Count:24
Complexity:420

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)N

Technology Process of 4-Amino-N-[3,5-bis(trifluoromethyl)phenyl]benzamide

There total 4 articles about 4-Amino-N-[3,5-bis(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: N-(3,5-bis(trifluoromethyl)phenyl)-4-nitrobenzamide

: 976-50-1
4-amino-N-(3,5-bis(trifluoromethyl)phenyl)benzamide

Guidance literature:: With iron; ammonium chloride; In methanol; water; at 70 ℃;
DOI:10.1039/c8md00413g

Reference yield: 83.7%

: 976-50-1
4-amino-N-(3,5-bis(trifluoromethyl)phenyl)benzamide

Guidance literature:: With iron; ammonium chloride; In methanol; water; at 70 ℃; for 5h;

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 976-50-1
4-amino-N-(3,5-bis(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0 °C

2: ammonium chloride; iron / methanol; water / 70 °C

With iron; ammonium chloride; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1039/c8md00413g