Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Base Information

• Chemical Name: Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
• CAS No.: 139036-69-4
• Molecular Formula: C₆₆H₆₂ClN₆O₁₁PSi
• Molecular Weight: 1209.76
• Mol file: 139036-69-4.mol

Synonyms:

Chemical Property of Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

There total 10 articles about Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-bromobenzyl alcohol (18982-54-2) → Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (139036-69-4)

Guidance literature:

Multi-step reaction with 7 steps

2: Mg / in Et₂O

3: oxalyl chloride / toluene

4: pyridine

5: H₂O / methanol

With oxalyl dichloride; water; magnesium; In pyridine; methanol; toluene;

DOI:10.1016/S0040-4039(00)94573-8

Reference yield:

(2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane (132286-87-4) → Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (139036-69-4)

Guidance literature:

Multi-step reaction with 6 steps

1: Mg / in Et₂O

2: oxalyl chloride / toluene

3: pyridine

4: H₂O / methanol

With oxalyl dichloride; water; magnesium; In pyridine; methanol; toluene;

DOI:10.1016/S0040-4039(00)94573-8

Reference yield:

2-(((tert-butyldiphenylsilyl)oxy)methyl)benzoic acid (132286-88-5) → Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (139036-69-4)

Guidance literature:

Multi-step reaction with 5 steps

1: oxalyl chloride / toluene

2: pyridine

3: H₂O / methanol

With oxalyl dichloride; water; In pyridine; methanol; toluene;

DOI:10.1016/S0040-4039(00)94573-8

upstream raw materials:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate

N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-benzamide

o-bromobenzyl alcohol

(2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane