132286-88-5

Upstream product

• 124-38-9 carbon dioxide 
• 132286-87-4 (2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 18982-54-2 o-bromobenzyl alcohol 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 129452-86-4 2-<(tert-butyldiphenylsilyloxy)methyl>benzoyl chloride 
• 139036-59-2 4-N-[2-(tert-butyldiphenylsilyloxymethyl)]benzoyl deoxycytidine 
• 139036-61-6 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 
• 139036-62-7 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-benzamide 
• 398148-63-5 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[2-oxo-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 129452-87-5 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-benzamide 
• 129452-88-6 N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-benzamide 
• 129452-89-7 N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-benzamide 
• 129452-93-3 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoyl]-N-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 
• 129452-90-0 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 129452-91-1 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 129452-92-2 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{2-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-6-oxo-1,6-dihydro-purin-9-yl}-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 139036-69-4 Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 139052-29-2 Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 

Relevant academic research and scientific papers

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).

MODULATORS OF HEMOGLOBIN

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.

Efficient and low cost synthesis of the 2-(tert-butyldiphenylsilyloxymethyl)benzoyl chloride for the protection of nucleobases

The title compound was easily obtained starting from cheap phthalide in four steps with an overall yield of 67%.

A new protected acyl protecting group for exocyclic amino functions of nucleobases

2-(Tert-butyldiphenylsilyloxymethyl)benzoyl chloride (SiOMB-Cl) reacts with the per-O-trimethylsilylated d-nucleosides C,G and A to give, after removal of the Si(Me)3 groups and 5′-O-protection with 4,4′-dimethoxytrityl chloride (DMT-Cl), the corresponding N-SiOMB-5′-O-DMT derivates, the SiOMB groups of which can easily be removed by fluoride ion. The SiOMB protected nucleosides proved to be suitable building units for the preparation of DNA fragments in solution and on a solid support.