Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester
CAS No.:76902-50-6
Molecular Formula:C₄₆H₄₀ClN₆O₈P
Molecular Weight:871.286
Hs Code.:

Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

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Chemical Property of Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

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Technology Process of Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

There total 3 articles about Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66884-45-5
(2R,3R,5S)-2-[6-(N-benzoylbenzamido)-9H-purin-9-yl]-5-[(benzoyloxy)methyl]oxolan-3-yl benzoate

: 76902-50-6
Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1 N NaOH

2: monomethoxytritylation

3: 1.) pyridine

With sodium hydroxide;
DOI:10.1016/0040-4039(80)88070-1