N-[4-(2-Bromoacetyl)Phenyl]Acetamide

Base Information

• Chemical Name: N-[4-(2-Bromoacetyl)Phenyl]Acetamide
• CAS No.: 21675-02-5
• Molecular Formula: C10H10BrNO2
• Molecular Weight: 256.099
• Hs Code.: 2925190090
• DSSTox Substance ID: DTXSID90494378
• Wikidata: Q72451285
• Mol file: 21675-02-5.mol

Synonyms:N-[4-(2-Bromoacetyl)Phenyl]Acetamide;21675-02-5;4-Acetamidophenacyl bromide;N-(4-(2-bromoacetyl)phenyl)acetamide;AKOS BBS-00004805;N-[4-(bromoacetyl)phenyl]acetamide;Acetamide, N-[4-(bromoacetyl)phenyl]-;4-acetylaminophenacyl bromide;SCHEMBL773314;4'-Acetamido-2-bromoacetophenone;DTXSID90494378;BDOHURFEYYDIQE-UHFFFAOYSA-N;WAA67502;MFCD00728749;AKOS000269477;AC-8447;AS-8786;CS-W004001;FT-0710716;EN300-110463;A878965

Chemical Property of N-[4-(2-Bromoacetyl)Phenyl]Acetamide

Chemical Property:

• Boiling Point: 433.168 °C at 760 mmHg
• Flash Point: 215.773 °C
• PSA: 46.17000
• Density: 1.531g/cm³
• LogP: 2.29560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 254.98949
• Heavy Atom Count: 14
• Complexity: 222

Purity/Quality:

97% ^*data from raw suppliers

N-[4-(2-Bromoacetyl)phenyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)CBr

Technology Process of N-[4-(2-Bromoacetyl)Phenyl]Acetamide

There total 5 articles about N-[4-(2-Bromoacetyl)Phenyl]Acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-(N-acetylamino)acetophenone (2719-21-3,150667-24-6) → 4-acetylaminophenacyl bromide (21675-02-5)

Guidance literature:

With aluminium trichloride; bromine; In tetrahydrofuran; at 0 ℃; for 40h;

DOI:10.1021/ja9635589

Reference yield: 61.0%

2-Bromoacetyl bromide (598-21-0) + Acetanilid (103-84-4) → 4-acetylaminophenacyl bromide (21675-02-5)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 50 ℃; for 16h;

Reference yield:

p-aminobenzophenone (99-92-3) → 4-acetylaminophenacyl bromide (21675-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / toluene / 20 °C

2: 63 percent / Br₂; AcOH / 60 °C

With bromine; acetic acid; In toluene;

DOI:10.1016/j.bmcl.2006.12.077

upstream raw materials:

2-Bromoacetyl bromide

Acetanilid

4-(N-acetylamino)acetophenone

p-aminobenzophenone

Downstream raw materials:

1-(4-acetylamino-phenacyl)-pyridinium; bromide

N-[4-(2-methyl-4-thiazolyl)phenyl]acetamide

N-[4-(2-allylamino-thiazol-4-yl)-phenyl]-acetamide

N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide