1-(5-Bromo-2-pyridyl)-2-thiourea

Base Information

• Chemical Name: 1-(5-Bromo-2-pyridyl)-2-thiourea
• CAS No.: 31430-38-3
• Molecular Formula: C₆H₆BrN₃S
• Molecular Weight: 232.104
• Hs Code.: 2933399090
• Mol file: 31430-38-3.mol

Synonyms:thiourea, N-(5-bromo-2-pyridinyl)-;

Chemical Property of 1-(5-Bromo-2-pyridyl)-2-thiourea

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 236-240℃
• Refractive Index: 1.764
• Boiling Point: 331.651 °C at 760 mmHg
• PKA: 11.69±0.70(Predicted)
• Flash Point: 154.377 °C
• PSA: 87.57000
• Density: 1.828 g/cm³
• LogP: 2.29330
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(5-Bromopyridin-2-yl)thiourea 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Bromo-2-pyridyl)-2-thiourea

There total 3 articles about 1-(5-Bromo-2-pyridyl)-2-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-bromo-2-pyridylamine (1072-97-5) + ammonium thiocyanate (1147550-11-5) → 1-(5-bromo-pyridin-2-yl)-thiourea (31430-38-3)

Guidance literature:

ammonium thiocyanate; With benzoyl chloride; In acetone; at 20 ℃; for 0.333333h; Heating / reflux;

5-bromo-2-pyridylamine; In acetone; for 0.5h; Heating / reflux;

Reference yield:

N-(5'-bromo-2'-pyridyl)-N'-benzoylthiourea (31430-37-2) → 1-(5-bromo-pyridin-2-yl)-thiourea (31430-38-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/j.bmcl.2007.11.076

Reference yield:

→ 1-(5-bromo-pyridin-2-yl)-thiourea (31430-38-3)

Guidance literature:

upstream raw materials:

N-(5'-bromo-2'-pyridyl)-N'-benzoylthiourea

5-bromo-2-pyridylamine

ammonium thiocyanate

Downstream raw materials:

(5-bromo-pyridine-2-yl)-thiazole-2-yl-amine

Refernces

• 1、 Kim, Soong-Hoon,Tokarski, John S.,Leavitt, Kenneth J.,Fink, Brian E.,Salvati, Mark E.,Moquin, Robert,Obermeier, Mary T.,Trainor, George L.,Vite, Gregory G.,Stadnick, Linda K.,Lippy, Jonathan S.,You, Dan,Lorenzi, Matthew V.,Chen, Ping. "Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA". . p. 634 - 639. Retrieved 2008/09/18.
• 2、 -. "Tyrosine kinase inhibitors". . . Retrieved 2008/06/13.