1,3-Dichloro-6,7-dimethoxyisoquinoline

Base Information

Chemical Name:1,3-Dichloro-6,7-dimethoxyisoquinoline
CAS No.:24623-42-5
Molecular Formula:C11H9 Cl2 N O2
Molecular Weight:258.104
Hs Code.:
European Community (EC) Number:808-613-2
DSSTox Substance ID:DTXSID70694713
Wikidata:Q72466016
Mol file:24623-42-5.mol

Synonyms:1,3-DICHLORO-6,7-DIMETHOXYISOQUINOLINE;24623-42-5;1,3-dichloro-6,7-dimethoxy-isoquinoline;SCHEMBL15020103;DTXSID70694713;PDJTYACMQQZNHN-UHFFFAOYSA-N;MFCD14704915;AKOS030231087;AT15479;NS-03954;SY207403;EN300-246293

Suppliers and Price of 1,3-Dichloro-6,7-dimethoxyisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
1,3-Dichloro-6,7-dimethoxyisoquinoline
250mg
$ 519.00

AK Scientific
1,3-Dichloro-6,7-dimethoxyisoquinoline
500mg
$ 873.00

Abosyn
1,3-dichloro-6,7-dimethoxyisoquinoline 95-98%
1g
$ 650.00

Total 9 raw suppliers

Chemical Property of 1,3-Dichloro-6,7-dimethoxyisoquinoline

Chemical Property:

PSA：31.35000
Density:1.367
LogP:3.55880
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:257.0010339
Heavy Atom Count:16
Complexity:242

Purity/Quality:

99% ^*data from raw suppliers

1,3-Dichloro-6,7-dimethoxyisoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C=C(N=C2Cl)Cl)OC

Technology Process of 1,3-Dichloro-6,7-dimethoxyisoquinoline

There total 7 articles about 1,3-Dichloro-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 63177-14-0
6,7-dimethoxyisoquinoline-1,3(2H,4H)-dione

: 24623-42-5
1,3-dichloro-6,7-dimethoxyisoquinoline

Guidance literature:: With P,P-dichlorophenylphosphine oxide; at 160 ℃; for 3h; Sealed tube;
DOI:10.1039/c7md00052a

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 24623-42-5
1,3-dichloro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: n-Butyl nitrite; hydrogenchloride / methanol; water / 0.25 h / 0 °C

2: sodium hydroxide; p-toluenesulfonyl chloride / water / 0.25 h / 20 - 80 °C

3: potassium carbonate / water-d2 / 2 h / 20 °C

4: sodium hydride / 3 h / 20 - 80 °C

5: hydrogenchloride / methanol; water / 1 h / 100 °C

6: P,P-dichlorophenylphosphine oxide / 3 h / 160 °C / Sealed tube

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; n-Butyl nitrite; sodium hydride; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide; In methanol; water; water-d2;
DOI:10.1039/c7md00052a

Reference yield:

: 2107-85-9
5,6-dimethoxy-indan-1,2-dione-2-oxime

: 24623-42-5
1,3-dichloro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; p-toluenesulfonyl chloride / water / 0.25 h / 20 - 80 °C

2: potassium carbonate / water-d2 / 2 h / 20 °C

3: sodium hydride / 3 h / 20 - 80 °C

4: hydrogenchloride / methanol; water / 1 h / 100 °C

5: P,P-dichlorophenylphosphine oxide / 3 h / 160 °C / Sealed tube

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; sodium hydride; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide; In methanol; water; water-d2;
DOI:10.1039/c7md00052a