3,4-Dichloro-6-phenylpyridazine

Base Information

• Chemical Name: 3,4-Dichloro-6-phenylpyridazine
• CAS No.: 64942-62-7
• Molecular Formula: C10H6 Cl2 N2
• Molecular Weight: 225.077
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00523845
• Wikidata: Q72467662
• Mol file: 64942-62-7.mol

Synonyms:3,4-DICHLORO-6-PHENYLPYRIDAZINE;64942-62-7;3-Phenyl-5,6-dichloropyridazine;3,4-dichloro-6-phenyl-pyridazine;SCHEMBL581664;3.4-dichloro-6-phenylpyridazine;DTXSID00523845;DGKIYVQEFBTNMF-UHFFFAOYSA-N;MFCD12828180;AKOS005073030;HD-0710;CS-0326735;A867787;J-511137

Chemical Property of 3,4-Dichloro-6-phenylpyridazine

Chemical Property:

• Melting Point: 164-165°
• Boiling Point: 406.7±40.0 °C(Predicted)
• PKA: -1.19±0.10(Predicted)
• PSA: 25.78000
• Density: 1.363
• LogP: 3.45040
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.9908036
• Heavy Atom Count: 14
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichloro-6-phenylpyridazine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN=C(C(=C2)Cl)Cl

Technology Process of 3,4-Dichloro-6-phenylpyridazine

There total 4 articles about 3,4-Dichloro-6-phenylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4,5,-dihydro-6-phenyl-2-(phenylmethyl)-3(2H)-pyridazinone (87769-64-0) → 3-chloro-6-phenylpyradazine (20375-65-9) + 3,4-dichloro-6-phenylpyridazine (64942-62-7)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 8h; Heating;

DOI:10.1002/jhet.5570200607

Reference yield: 44.0%

4,5,-dihydro-6-phenyl-2-(phenylmethyl)-3(2H)-pyridazinone (87769-64-0) → 3,4-dichloro-6-phenylpyridazine (64942-62-7)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 120 ℃; for 12h;

Reference yield: 10.0%

6-phenyl-2,3,4,5-tetrahydropyridazin-3-one (1011-46-7) → 3-chloro-6-phenylpyradazine (20375-65-9) + 3,4-dichloro-6-phenylpyridazine (64942-62-7)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 8h; Heating;

DOI:10.1002/jhet.5570200607

upstream raw materials:

6-phenyl-2,3,4,5-tetrahydropyridazin-3-one

4,5,-dihydro-6-phenyl-2-(phenylmethyl)-3(2H)-pyridazinone

succinylbenzene

Downstream raw materials:

N'-(3-Chloro-6-phenyl-pyridazin-4-yl)-N,N-dimethyl-propane-1,3-diamine

3-chloro-6-phenyl-pyridazin-4-ylamine

(3-chloro-6-phenyl-pyridazin-4-yl)-phenethyl-amine

3-chloro-6-phenylpyridazin-4-ol

Refernces

• 1、 Zhou, Gang,Ting, Pauline C.,Aslanian, Robert,Cao, Jianhua,Kim, David W.,Kuang, Rongze,Lee, Joe F.,Schwerdt, John,Wu, Heping,Jason Herr,Zych, Andrew J.,Yang, Jinhai,Lam, Sang,Wainhaus, Samuel,Black, Todd A.,McNicholas, Paul M.,Xu, Yiming,Walker, Scott S.. "SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors". experimental part. p. 2890 - 2893. Retrieved 2011/06/24.
• 2、 Hu, Wenhui,Ralay Ranaivo, Hantamalala,Roy, Saktimayee M.,Behanna, Heather A.,Wing, Laura K.,Munoz, Lenka,Guo, Ling,Van Eldik, Linda J.,Watterson, D. Martin. "Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits". . p. 414 - 418. Retrieved 2007/10/03.