1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
• CAS No.: 1612223-67-2
• Molecular Formula: C₂₆H₂₉BrClN₃O₄
• Molecular Weight: 562.891
• Mol file: 1612223-67-2.mol

Synonyms:

Chemical Property of 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

There total 5 articles about 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chlorophenylboronic acid (63503-60-6) → 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (1612223-67-2)

Guidance literature:

Multi-step reaction with 4 steps

1: copper diacetate; pyridine / 1,2-dichloro-ethane / 72 h / 55 °C

2: diethyl ether / 2 h / -78 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: acetonitrile / 80 °C

With pyridine; copper diacetate; triethylamine; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jm500463c

Reference yield:

4-bromo-3-(3-chlorophenoxy)-2-methoxybenzaldehyde (1612223-64-9) → 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (1612223-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 2 h / -78 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: acetonitrile / 80 °C

With triethylamine; In diethyl ether; dichloromethane; acetonitrile;

DOI:10.1021/jm500463c

Reference yield:

4-bromo-2-hydroxy-3-methoxy benzaldehyde (1427439-23-3) → 1-[(3S)-1-{1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propyl}piperidin-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione (1612223-67-2)

Guidance literature:

Multi-step reaction with 4 steps

1: copper diacetate; pyridine / 1,2-dichloro-ethane / 72 h / 55 °C

2: diethyl ether / 2 h / -78 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: acetonitrile / 80 °C

With pyridine; copper diacetate; triethylamine; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jm500463c

upstream raw materials:

4-bromo-3-(3-chlorophenoxy)-2-methoxybenzaldehyde

1-[4-bromo-3-(3-chlorophenoxy)-2-methoxyphenyl]propan-1-ol

(S)-5-methyl-1-(piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione

C₁₇H₁₈BrClO₅S

Downstream raw materials:

2-(3-chlorophenoxy)-3-methoxy-4-{1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl}benzoic acid

2-(3-chlorophenoxy)-3-methoxy-4-{(1R)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl}benzoic acid

2-(3-chlorophenoxy)-3-methoxy-4-{(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl}benzoic acid

C₂₇H₂₉ClN₄O₄